Activity of the Lichen Usnea steineri and its Major Metabolites against Gram-positive, Multidrug-resistant Bacteria

Autor(es)

Tozatti, Marcos G. ^[1] ; Ferreira, Daniele S. ^[1] ; Bocalon Flauzino, Luzio G. ^[1] ; Moraes, Thais da Silva ^[1] ; Martins, Carlos H. G. ^[1] ; Groppo, Milton ^[2] ; Andrade e Silva, Marcio L. ^[1] ; Januario, Ana H. ^[1] ; Pauletti, Patricia M. ^[1] ; Cunha, Wilson R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Biol, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT COMMUNICATIONS; v. 11, n. 4, p. 493-496, APR 2016.
• Citações Web of Science: 2

Resumo

The antimicrobial activity and possible synergistic effects of extracts and compounds isolated from Usnea steineri were evaluated against four resistant bacterial species. A phytochemical study of the acetone extract of U. steineri resulted in the isolation and characterization of difractaic acid and (+)-usnic acid as the main compounds. The acetone extract showed strong activity (less than 10 mu g/mL) against resistant strains of Staphylococcus epidermidis and Enterococcus faecalis, and (+)-usnic acid exhibited strong activity against S. epidermidis (MIC 3.12 mu g/mL), S. aureus and S. haemolyticus (MIC 12.5 mu g/mL). Combinations of penicillin and tetracycline with (+)-usnic acid did not show any synergistic antimicrobial effects. Difractaic acid was inactive. Our results showed that the acetone extract of U. steineri possesses significant in vitro antimicrobial activity, which is likely related to the presence of (+)-usnic acid. (AU)

• Processo FAPESP: 12/16182-8 - Estudo químico e ensaios biológicos com espécies do cerrado visando à busca de substâncias antiparasitárias
• Beneficiário: Wilson Roberto Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/22636-1 - Busca por substâncias naturais com potencial aplicação frente a bactérias resistentes
• Beneficiário: Marcos Gomide Tozatti
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto