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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Activity of the Lichen Usnea steineri and its Major Metabolites against Gram-positive, Multidrug-resistant Bacteria

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Author(s):
Tozatti, Marcos G. [1] ; Ferreira, Daniele S. [1] ; Bocalon Flauzino, Luzio G. [1] ; Moraes, Thais da Silva [1] ; Martins, Carlos H. G. [1] ; Groppo, Milton [2] ; Andrade e Silva, Marcio L. [1] ; Januario, Ana H. [1] ; Pauletti, Patricia M. [1] ; Cunha, Wilson R. [1]
Total Authors: 10
Affiliation:
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas, BR-14404600 Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Biol, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NATURAL PRODUCT COMMUNICATIONS; v. 11, n. 4, p. 493-496, APR 2016.
Web of Science Citations: 2
Abstract

The antimicrobial activity and possible synergistic effects of extracts and compounds isolated from Usnea steineri were evaluated against four resistant bacterial species. A phytochemical study of the acetone extract of U. steineri resulted in the isolation and characterization of difractaic acid and (+)-usnic acid as the main compounds. The acetone extract showed strong activity (less than 10 mu g/mL) against resistant strains of Staphylococcus epidermidis and Enterococcus faecalis, and (+)-usnic acid exhibited strong activity against S. epidermidis (MIC 3.12 mu g/mL), S. aureus and S. haemolyticus (MIC 12.5 mu g/mL). Combinations of penicillin and tetracycline with (+)-usnic acid did not show any synergistic antimicrobial effects. Difractaic acid was inactive. Our results showed that the acetone extract of U. steineri possesses significant in vitro antimicrobial activity, which is likely related to the presence of (+)-usnic acid. (AU)

FAPESP's process: 12/16182-8 - Chemical study and biological assays with species of the cerrado searching to antiparasitic substances
Grantee:Wilson Roberto Cunha
Support Opportunities: Regular Research Grants
FAPESP's process: 12/22636-1 - Search for natural compounds with potential use against resistant bacteria
Grantee:Marcos Gomide Tozatti
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)