Chemical study and biological assays with species of the cerrado searching to antiparasitic substances

• Grant number: 12/16182-8
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2012
• End date: October 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wilson Roberto Cunha
• Grantee: Wilson Roberto Cunha
• Host Institution: Reitoria. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated researchers: Lizandra Guidi Magalhães ; Márcio Luís Andrade e Silva

Abstract

Natural products are used by man since ancient times. The search for relief and cure of diseases by eating leaves and herbs may have been one of the earliest forms of using natural products. Chemistry of Natural Products represents, within the search area with plant species, a point of great importance and value, in that only through the use of phytochemicals methods can isolate new substances and obtain the correct determination of their chemical structures and subsequently obtainment of derivatives by partial or total synthesis. The introduction of new technologies became the medicinal chemistry in its broadest conception, expanding its interdisciplinary character. The new molecular biology and genetic techniques allowed the isolation and purification of many enzymes and receptors directly associated with the diseases, representing authentic molecular targets for new drugs. Most drugs available in modern therapy are obtained by synthesis, but many of them were originally extracted from plants or used a prototype that, in turn, was also extracted from plants. This project focuses on the preparation of crude extracts of natural sources (Davilla elliptica, Vellozia variabilis, Gochnatia pulchra, Usnea steineri, Erythroxylum suberosum, Kilmeyera variabilis and Miconia langsdorffii) that will be collected in "Cerrado" areas. These extracts will be evaluated in vitro against the parasites that cause leishmaniasis, schistosomiasis and Chagas disease, thus aiming the obtainment of the most promising extracts for further fractionation and isolation of the major constituents in order to obtain the active compounds. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LUCARINI, R.; TOZATTI, M. G.; SILVA, M. L. A.; GIMENEZ, V. M. M.; PAULETTI, P. M.; GROPPO, M.; TURATTI, I. C. C.; CUNHA, W. R.; MARTINS, C. H. G.. Antibacterial and anti-inflammatory activities of an extract, fractions, and compounds isolated from Gochnatia pulchra aerial parts. Brazilian Journal of Medical and Biological Research, v. 48, n. 9, p. 822-830, SEP 2015. (12/16182-8, 10/02066-0, 08/07329-0)

LUCARINI, RODRIGO; MAGALHAES, LIZANDRA G.; RODRIGUES, VANDERLEI; SOUZA, JULIA M.; TOZATTI, MARCOS G.; PIRES, REGINA H.; CUNHA, WILSON R.; MARTINS, CARLOS H. G.. Antiprotozal and Antihelminthic Evaluation of the Hydroalcoholic Extract, Fractions and Compounds of Gochnatia pulchra. Latin American Journal of Pharmacy, v. 35, n. 4, p. 762-767, MAY 2016. (12/16182-8, 10/02066-0, 08/07329-0)

TOZATTI, MARCOS G.; FERREIRA, DANIELE S.; BOCALON FLAUZINO, LUZIO G.; MORAES, THAIS DA SILVA; MARTINS, CARLOS H. G.; GROPPO, MILTON; ANDRADE E SILVA, MARCIO L.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; CUNHA, WILSON R.. Activity of the Lichen Usnea steineri and its Major Metabolites against Gram-positive, Multidrug-resistant Bacteria. NATURAL PRODUCT COMMUNICATIONS, v. 11, n. 4, p. 493-496, APR 2016. (12/16182-8, 12/22636-1)

ACESIO, NATHALIA OLIVEIRA; DE OLIVEIRA, POLLYANNA FRANCIELLI; PEREIRA MASTROCOLA, DAIANE FERNANDA; DE SOUZA LIMA, ILDERCILIO MOTA; MUNARI, CARLA CAROLINA; FERREIRA LUCATTI SATO, VANIA LUIZA; SILVA SOUZA, ANDRESSA APARECIDA; BOCALON FLAUZINO, LUZIO GABRIEL; CUNHA, WILSON ROBERTO; TAVARES, DENISE CRISPIM. Modulatory Effect of Betulinic Acid on the Genotoxicity Induced by Different Mutagens in V79 Cells. Evidence-based Complementary and Alternative Medicine, v. 2016, p. 6-pg., 2016-01-01. (12/16182-8, 11/05732-4)

ACESIO, NATHALIA OLIVEIRA; DE OLIVEIRA, POLLYANNA FRANCIELLI; PEREIRA MASTROCOLA, DAIANE FERNANDA; DE SOUZA LIMA, ILDERCILIO MOTA; MUNARI, CARLA CAROLINA; FERREIRA LUCATTI SATO, VANIA LUIZA; SILVA SOUZA, ANDRESSA APARECIDA; BOCALON FLAUZINO, LUZIO GABRIEL; CUNHA, WILSON ROBERTO; TAVARES, DENISE CRISPIM. Modulatory Effect of Betulinic Acid on the Genotoxicity Induced by Different Mutagens in V79 Cells. Evidence-based Complementary and Alternative Medicine, 2016. (11/05732-4, 12/16182-8)

FERREIRA, DANIELE S.; TOZATTI, MARCOS G.; SOUZA, MARIA G. M.; MARTINS, CARLOS H. G.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; SILVA, MARCIO L. A.; CUNHA, WILSON R.. Antimicrobial Activity of Compounds Isolated from Rosmarinus officinalis and Semi-Synthetic Derivatives against Multidrug-Resistant Bacteria. Latin American Journal of Pharmacy, v. 35, n. 5, p. 862-868, 2016. (12/16182-8)