Evaluation of genotoxicity of general anesthesia maintained with desflurane in patients under minor surgery

Autor(es)

Nogueira, Flavia R. ^[1] ; Braz, Leandro G. ^[1] ; de Andrade, Leonardo R. ^[1] ; de Carvalho, Ana Lygia R. ^[1] ; Vane, Luiz A. ^[1] ; Modolo, Norma Sueli P. ^[1] ; Aun, Aline G. ^[1] ; Souza, Katina M. ^[1] ; Braz, Jose Reinaldo C. ^[1] ; Braz, Mariana G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Anestesiol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Environmental and Molecular Mutagenesis; v. 57, n. 4, p. 312-316, MAY 2016.
• Citações Web of Science: 3

Resumo

There is controversy over the genotoxic effects of volatile anesthetics. The available literature on the genotoxicity of desflurane, one of the newest volatile halogenated agents used for general anesthesia maintenance, is scarce. This study aimed to evaluate the genotoxic potential of desflurane in 15 patients without comorbidities, of both sexes, who underwent minor surgeries lasting at least 90 min. Patients enrolled in the study received desflurane anesthesia (6%); blood samples were collected before anesthesia induction (T0), 90 min after the beginning of anesthesia (T1), and on the day following surgery (T2). DNA damage was evaluated in lymphocytes using the alkaline comet assay. We found statistically significant increases in DNA damage in T2 samples compared to T0. The findings suggest that desflurane anesthesia induces DNA strand breaks/alkali-labile sites on the day after minimally invasive surgery in healthy patients. Environ. Mol. Mutagen. 57:312-316, 2016. (c) 2016 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 13/16842-0 - A anestesia inalatória com desflurano associada ou não ao óxido nitroso é genotóxica e induz estresse oxidativo em pacientes?
• Beneficiário: Jose Reinaldo Cerqueira Braz
• Modalidade de apoio: Auxílio à Pesquisa - Regular