Exhumation of Wistar rats experimentally exposed to the carbamate pesticides aldicarb and carbofuran: A pathological and toxicological study

Autor(es)

de Siqueira, Adriana ^[1] ; Almeida Rodrigues, Karina Borges ^[1] ; Goncalves-Junior, Vagner ^[1] ; Calefi, Atilio Sersun ^[1] ; Fukushima, Andre Rinaldi ^[1] ; Campusano Cuevas, Silvia Elena ^[1] ; Spinosa, Helenice de Souza ^[1] ; Maiorka, Paulo Cesar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Sch Vet Med & Anim Sci, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY; v. 68, n. 6, p. 307-314, JUN 2016.
• Citações Web of Science: 1

Resumo

Exhumation is required for the investigation of suspicions deaths when a body is buried and is usually performed under court order. Exhumation of animals is not a routine practice in forensic pathology. In this study, 30 male 70-day-old Wistar rats were experimentally exposed to the carbamate pesticides aldicarb and carbofuran. Toxicological, macroscopic and microscopic examinations were performed. Groups of 3 animals (2 exposed and 1 control) were evaluated at 24 h, 3 days, 5 days, 7 days and 10 days post-mortem. In histopathological examination, the brain, liver, lungs and kidneys were assessed, and for toxicological analysis, the gastric contents, liver, vitreous humor, skeletal muscle and larvae (when available) were collected. The pesticides were detected by HPLC and quantified in the analyzed matrices, and a possible delay in tissue putrefaction due to the pesticides was observed. This study has revealed that it is possible to exhume animals for investigations of possible poisoning by carbamates and has demonstrated that the exhumation of an animal in a suspected case of poisoning should not be ruled out. The increasing demand for investigations of suspicious animal deaths, e.g., in cases of poisoning, will likely lead to an increase in the use of this type of procedure in veterinary pathology. (C) 2016 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 12/23645-4 - Estudo de alterações patológicas em situações ligadas à perícia em medicina veterinária
• Beneficiário: Paulo César Maiorka
• Modalidade de apoio: Auxílio à Pesquisa - Regular