Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Syntheses and characterization of amphiphilic quaternary ammonium chitosan derivatives

Texto completo
Autor(es):
Pedro, Rafael de Oliveira [1] ; Schmitt, Carla C. [1] ; Neumann, Miguel G. [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Caixa Postal 780, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Carbohydrate Polymers; v. 147, p. 97-103, AUG 20 2016.
Citações Web of Science: 17
Resumo

Amphiphilic chitosan derivatives possess improved physico-chemical properties and could be used as carriers in drug delivery systems. The aim of this study was to investigate the behaviour of an amphiphilic system involving (5-pentyl) trimethylammonium and dodecyl aldehyde-modified chitosan. Amphiphilic chitosan derivatives were synthesized and characterized by (HNMR)-H-1 and ATR-FTIR spectroscopy. Self-assembled aggregates formed in aqueous solution have hydrophobic cores that were characterized by fluorescence spectroscopy using pyrene as probe and dynamic light scattering (DLS). The critical aggregation concentration of the aggregates in water varied from 0.004 to 0.037 g/L and the average size distribution was in the 230-500 nm range. The zeta-potential (+15.5 to +44.8 mV) confirmed that the surfaces of the aggregates were positively charged and stable in physiological-like environments. TEM images suggest that the aggregates have a spherical shape, showing good agreement with DLS results. These results suggest that the synthesized copolymers have the capability of being used as carriers for hydrophobic drugs. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 12/19656-0 - Fotoiniciação de polimerização e degradação de polímeros multicomponentes
Beneficiário:Carla Cristina Schmitt Cavalheiro
Linha de fomento: Auxílio à Pesquisa - Regular