Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok

Autor(es)

Luisa Z Moreno ; Frederico S Kremer ; Fabiana Miraglia ; Ana P Loureiro ; Marcus R Eslabao ; Odir A Dellagostin ; Walter Lilenbaum ; Andrea M Moreno

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 111, n. 8, p. 539-541, Ago. 2016.
• Citações Web of Science: 1

Resumo

Leptospira kirschneri is one of the pathogenic species of the Leptospira genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/05 and the comparative genomic analysis with Brazilian human strain 61H. The M36/05 strain caused pulmonary hemorrhagic lesions in the hamster model, showing high virulence. The studied genomes presented high symmetrical identity and the in silico multilocus sequence typing analysis resulted in a new allelic profile (ST101) that so far has only been associated with the Brazilian L. kirschneri serogroup Pomona serovar Mozdok strains. Considering the environmental conditions and high genomic similarity observed between strains, we suggest the existence of a Brazilian L. kirschneri serogroup Pomona serovar Mozdok lineage that could represent a high public health risk; further studies are necessary to confirm the lineage significance and distribution. (AU)

• Processo FAPESP: 13/17136-2 - Caracterização de estirpes de Leptospira isoladas no Brasil através de tipificação por eletroforese em campo pulsado (PFGE) e análise comparativa de genomas
• Beneficiário: Luisa Zanolli Moreno
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/18290-0 - Caracterização de estirpes de Leptospira isoladas no Brasil através da tipagem por sequenciamento de multilocus (MLST)
• Beneficiário: Andrea Micke Moreno
• Linha de fomento: Auxílio à Pesquisa - Regular