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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok

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Author(s):
Luisa Z Moreno [1] ; Frederico S Kremer [2] ; Fabiana Miraglia [3] ; Ana P Loureiro [4] ; Marcus R Eslabao [5] ; Odir A Dellagostin [6] ; Walter Lilenbaum [7] ; Andrea M Moreno [8]
Total Authors: 8
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Laboratório de Epidemiologia Molecular e Resistência a Antimicrobianos - Brasil
[2] Universidade Federal de Pelotas. Centro de Desenvolvimento Tecnológico - Brasil
[3] Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Laboratório de Bacteriologia Veterinária - Brasil
[4] Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Laboratório de Bacteriologia Veterinária - Brasil
[5] Universidade Federal de Pelotas. Centro de Desenvolvimento Tecnológico - Brasil
[6] Universidade Federal de Pelotas. Centro de Desenvolvimento Tecnológico - Brasil
[7] Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Laboratório de Bacteriologia Veterinária - Brasil
[8] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Laboratório de Epidemiologia Molecular e Resistência a Antimicrobianos - Brasil
Total Affiliations: 8
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 111, n. 8, p. 539-541, 2016-07-11.
Abstract

Leptospira kirschneri is one of the pathogenic species of the Leptospira genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/05 and the comparative genomic analysis with Brazilian human strain 61H. The M36/05 strain caused pulmonary hemorrhagic lesions in the hamster model, showing high virulence. The studied genomes presented high symmetrical identity and the in silico multilocus sequence typing analysis resulted in a new allelic profile (ST101) that so far has only been associated with the Brazilian L. kirschneri serogroup Pomona serovar Mozdok strains. Considering the environmental conditions and high genomic similarity observed between strains, we suggest the existence of a Brazilian L. kirschneri serogroup Pomona serovar Mozdok lineage that could represent a high public health risk; further studies are necessary to confirm the lineage significance and distribution. (AU)

FAPESP's process: 13/17136-2 - Characterization of Leptospira strains isolated in Brazil by pulsed field gel electrophoresis (PFGE) typing and comparative genomic analysis.
Grantee:Luisa Zanolli Moreno
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/18290-0 - Characterization of Leptospira strains isolated in Brazil through multiloccus sequence typing (MLST)
Grantee:Andrea Micke Moreno
Support Opportunities: Regular Research Grants