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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Imiquimod treatment for Equus caballus papillomavirus infection in equine aural plaques

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Autor(es):
Zakia, Luiza S. ; Olivo, Giovane ; Basso, Roberta M. ; Mira, Juliana ; Herman, Mariana ; Araujo, Jr., Joao P. ; Borges, Alexandre S. ; Oliveira-Filho, Jose P.
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: VETERINARY DERMATOLOGY; v. 27, n. 3, p. 175+, JUN 2016.
Citações Web of Science: 3
Resumo

Background - Aural plaques are a dermatopathy associated with Equus caballus papillomavirus (EcPV). This disease affects horses of all ages, genders and breeds, and causes sensitivity of the ears. Hypothesis/Objectives - The aim of this study was to evaluate the clinical efficacy of 5% imiquimod cream for the treatment of aural plaques and to compare the PCR detection of EcPV 3, 4, 5 and 6 before and after treatment. Animals - Eight horses diagnosed with aural plaques (14 ears) were used. Three mares with unilateral aural plaques were used as untreated controls. Methods - Imiquimod cream was applied every 48 h until complete resolution of the aural plaques was observed. Animals were evaluated clinically for 180 days after the end of treatment. PCR for detecting EcPV 3, 4, 5 and 6 was performed using aural plaque biopsies collected before and at 90 days after the end of treatment. Results - Clinical resolution was observed in 93% of the treated ears. Imiquimod treatment promoted the clearance of EcPV in 71.4% of the treated ears. Clinical remission of the aural plaques and changes in EcPV DNA positivity between the first and second biopsies were not observed in the control group. In 75% of horses, sedation was required in order to carry out pretreatment cleaning. Conclusions - The results of this study support the hypothesis that 5% imiquimod cream may be used as an effective treatment for aural plaques in horses. (AU)

Processo FAPESP: 13/13973-7 - Detecção do DNA dos EcPVs em amostras de placa aural antes e após o tratamento com imiquimod.
Beneficiário:Luiza Stachewski Zakia
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/15995-8 - Estudo etiológico da placa aural em equinos
Beneficiário:José Paes de Oliveira Filho
Linha de fomento: Auxílio à Pesquisa - Regular