Early Life and Postnatal Western Diet Feeding and Susceptibility to Chemically Induced Colonic Aberrant Crypt Foci in Male Rats Offspring

Autor(es)

Dionisio Lopes, Gisele Aparecida ; Correa Dias, Marcos ; Fernando Barbisan, Luis ; Marchesan Rodrigues, Maria Aparecida

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 68, n. 5, p. 811-817, 2016.
• Citações Web of Science: 0

Resumo

The modifying effects of a Western diet (WD) during early life on the susceptibility to colon carcinogenesis induced by dimethylhydrazine (DMH) were examined in male rats as later adults. Three groups were studied: a lifetime control diet-fed group, a test group fed WD since pregnancy from dams until postnatal day (PND) 42, and a group fed WD at adulthood. At PND 70, all groups received the carcinogen DMH and were euthanized 10wk later. Colonic aberrant crypt foci (ACF) were scored (number and crypt multiplicity) and the altered pattern of -catenin expression was evaluated in the colonic lesions. ACF multiplicity (4 crypts) was significantly higher in the group fed WD at early life than in the group fed the control diet. ACF number, crypt multiplicity, and the number of high-grade dysplastic lesions were significantly higher in the group fed WD at adulthood than in the groupfed the control diet. The number of lesions with altered -catenin expression was higher in the groups receiving WD at early life or at adulthood than in the lifetime control-diet-fed group. These findings indicate that WD exposure at early life increased the susceptibility to colon carcinogenesis at adulthood. (AU)

• Processo FAPESP: 08/53366-4 - Fatores ambientais de risco para câncer: análise em modelos experimentais de carcinogênese do trato gastrointestinal. Projeto 1: Exposição à dieta ocidental durante a gestação, lactação, fase juvenil
• Beneficiário: Maria Aparecida Marchesan Rodrigues Kobayasi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/57408-0 - Exposicao a dieta ocidental durante a gestacao, lactacao, fase juvenil e susceptibilidade a carcinogenese quimica do colon em ratos adultos da linhagem sprague dawley.
• Beneficiário: Gisele Aparecida Dionísio Lopes
• Modalidade de apoio: Bolsas no Brasil - Mestrado