Metabolic profiles of planktonic and biofilm cells of Candida orthopsilosis

Autor(es)

Pires, Regina Helena ; Cataldi, Thais Regiani ; Franceschini, Livia Maria ; Labate, Monica Veneziano ; Fusco-Almeida, Ana Marisa ; Labate, Carlos Alberto ; Palma, Mario Sergio ; Soares Mendes-Giannini, Maria Jose

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 11, n. 10, p. 1299-1313, OCT 2016.
• Citações Web of Science: 1

Resumo

Aim: This study aims to understand which Candida orthopsilosis protein aids fungus adaptation upon its switching from planktonic growth to biofilm. Materials \& methods: Ion mobility separation within mass spectrometry analysis combination were used. Results: Proteins mapped for different biosynthetic pathways showed that selective ribosome autophagy might occur in biofilms. Glucose, used as a carbon source in the glycolytic flux, changed to glycogen and trehalose. Conclusion: Candida orthopsilosis expresses proteins that combine a variety of mechanisms to provide yeasts with the means to adjust the catalytic properties of enzymes. Adjustment of the enzymes helps modulate the biosynthesis/degradation rates of the available nutrients, in order to control and coordinate the metabolic pathways that enable cells to express an adequate response to nutrient availability. (AU)

• Processo FAPESP: 11/12734-3 - Candida parapsilosis e C. orthopsilosis isoladas de águas de hemodiálise. Aplicação de metodologias proteomicas e de fotocatálise.
• Beneficiário: Regina Helena Pires
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/01270-9 - Candida parapsilosis e C. orthopsilosis isoladas de águas de hemodiálise: aplicação de metodologias proteômicas e de fotocatálise
• Beneficiário: Maria José Soares Mendes Giannini
• Modalidade de apoio: Auxílio à Pesquisa - Regular