Immunoexpression of hoxb7 and hoxb9 in salivary gland tumours

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Fonseca, Felipe Paiva ; Bingle, Lynne ; Santos-Silva, Alan Roger ; Lopes, Marcio Ajudarte ; Coletta, Ricardo D. ; Benevenuto de Andrade, Bruno Augusto ; Mariano, Fernanda Viviane ; Kowalski, Luiz Paulo ; Carrinho Ayroza Rangel, Ana Lucia ; Martins, Manoela Domingues ; Meurer, Luise ; Hunter, Keith D. ; Speight, Paul M. ; Vargas, Pablo Agustin

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 45, n. 9, p. 672-681, OCT 2016.
• Citações Web of Science: 0

Resumo

BackgroundSalivary gland carcinomas are uncommon neoplasms and the identification of new prognostic indicators could improve their management. HOXB7 and HOXB9 are members of the class I homeobox-containing genes important for normal embryogenesis and that are dysregulated in several human neoplasms. This study investigated HOXB7 and HOXB9 expressions in salivary gland tumourigenesis, their correlation with neoplastic proliferative and angiogenic features and their importance as prognostic markers. MethodsA hundred and fifty salivary gland tumours were organized in tissue microarray and expressions of CD105, Ki67, HOXB7 and HOXB9 were determined through immunohistochemistry. Reactions were quantified and correlated with clinicopathological parameters. ResultsIn normal glands, HOXB7 was found in basal cells, whereas HOXB9 was seen in serous acinar and scattered ductal cells. Malignancies exhibited an increased vascular density, proliferative index, HOXB7 and HOXB9 expressions when compared with pleomorphic adenoma and Warthin's tumour. Significant correlation was found between HOXB7 and CD105 (P = 0.004) in adenoid cystic carcinomas, and HOXB7 higher expression significantly correlated with the presence of paresthesia (P = 0.02). No marker exhibited a significant association with survival rates (P > 0.05). ConclusionHOXB7 and HOXB9 were expressed in normal salivary gland and were present in benign and malignant tumours derived from these structures, and HOXB7 significantly correlated with neoangiogenesis in AdCC. These findings suggest that both proteins might play a role in salivary gland tumourigenesis, but they were not significant prognostic determinants in this sample. (AU)

• Processo FAPESP: 12/10781-7 - Análise da expressão de citoqueratinas, do padrão angiogênico, proliferativo e de conteúdo de DNA celular de tumores de glândulas salivares
• Beneficiário: Pablo Agustin Vargas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/07519-9 - Semaphorinas e neuropilinas em tumores de glândulas salivares
• Beneficiário: Felipe Paiva Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/53839-2 - Criação do Laboratório de Patologia Digital através do uso do escaneador de lâminas histológicas (Aperio® Scanscope CS)
• Beneficiário: Oslei Paes de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários