Straightforward synthesis and antioxidant studies of chalcogenoaziridines

Autor(es)

Borges, Rodrigo ; Andrade, Floyd C. D. ; Schwab, Ricardo S. ; Sousa, Fernanda S. S. ; de Souza, Maurice Neto ; Savegnago, Lucielli ; Schneider, Paulo H.

• Tipo de documento: Artigo Científico
• Fonte: Tetrahedron Letters; v. 57, n. 31, p. 3501-3504, AUG 3 2016.
• Citações Web of Science: 4

Resumo

Herein we reported the synthesis of chalcogenoaziridines through the introduction of the organoselenium moiety in the aziridine framework through the nucleophilic substitution of the OTs leaving group. In addition, the antioxidant activity, as reflected by free radical scavenging, was also evaluated. The new seleno aziridine 6a showed more effective antioxidant compared to other compounds. These findings also suggest that seleno aziridine 6a is a promising antioxidant and that its activity is not influenced by the presence of the substituents attached into the aromatic ring. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 13/06558-3 - Catálise metálica assimétrica: preparação de alcoóis quirais e seus derivados a partir de reagentes orgânicos de zinco poli-funcionalizados e aplicação de novos ligantes quirais suportados em nanopartículas magnéticas
• Beneficiário: Ricardo Samuel Schwab
• Modalidade de apoio: Auxílio à Pesquisa - Regular