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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Does Pain in the Neonatal Period Influence Motor and Sensory Functions in a Similar Way for Males and Females During Post-Natal Development in Rats?

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Autor(es):
do Carmo, Elisabete de Cassia ; Sanada, Luciana Sayuri ; Berto Machado, Nathalia Leilane ; Sassoli Fazan, Valeria Paula
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: PAIN MEDICINE; v. 17, n. 8, p. 1520-1529, AUG 2016.
Citações Web of Science: 2
Resumo

Objective Early pain experiences can lead to disruption in the long-term responses to pain and in abnormal development and behavior in rodents. We evaluated the sensory and motor development of Wistar rats after exposure to painful stimulation ( repetitive needle prickling) immediately after birth. MethodsaEuro integral Male and female rats were followed up to 6 months of life, and sensory and motor functions were investigated by testing paw withdrawal with von Frey filaments, calibrated forceps (CF), and grip strength (GS) tests. ResultsaEuro integral Body weight increased with age and tended to be smaller in pain groups compared with their controls of the same sex. GS values also increased with age in controls but were stable and even decreased in pain groups from 120 up to 180 days. The von Frey filaments test showed higher values on the nonstimulated paws in male and female pain groups, with no differences between sides on the controls. The CF test showed smaller values on the stimulated paws in the pain group, with no differences between sides on the controls. ConclusionsaEuro integral Pain in the neonatal period influences sensory and motor functions negatively during development in male and female rats, even long term after the painful stimulus is ceased. The neonatal injury-induced hypersensitivity is persistent, and male and female rats respond similarly to the stimulus. (AU)

Processo FAPESP: 13/01111-0 - Estudo da velocidade de condução nervosa, sensitiva e motora, em ratos espontaneamente hipertensos (SHR), segundo a evolução da hipertensão
Beneficiário:Valéria Paula Sassoli Fazan
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/07265-4 - Avaliação do desenvolvimento das fibras mielínicas e amielínicas dos nervos sural e tibial pós estímulos nociceptivos na fase neonatal
Beneficiário:Luciana Sayuri Sanada
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 10/04116-5 - Análise comportamental, funcional e morfológica dos efeitos da estimulação nociceptiva durante o período neonatal em ratos Wistar de diferentes gêneros e idades
Beneficiário:Nathalia Leilane Berto Machado
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/00231-0 - Ultraestrutura e morfometria do nervo depressor aórtico em ratos com diabete induzido experimentalmente: efeito do tratamento com insulina
Beneficiário:Valéria Paula Sassoli Fazan
Linha de fomento: Auxílio à Pesquisa - Regular