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Lesseur, Corina ; Diergaarde, Brenda ; Olshan, Andrew F. ; Wunsch-Filho, Victor ; Ness, Andrew R. ; Liu, Geoffrey ; Lacko, Martin ; Eluf-Neto, Jose ; Franceschi, Silvia ; Lagiou, Pagona ; Macfarlane, Gary J. ; Richiardi, Lorenzo ; Boccia, Stefania ; Polesel, Jerry ; Kjaerheim, Kristina ; Zaridze, David ; Johanson, Mattias ; Menezes, Ana M. ; Curado, Maria Paula ; Robinson, Max ; Ahrens, Wolfgang ; Canova, Cristina ; Znaor, Ariana ; Castellsague, Xavier ; Conway, David I. ; Holcatova, Ivana ; Mates, Dana ; Vidensky, Marta ; Healy, Claire M. ; Szeszenia-Dbrowska, Neonila ; Fabianova, Eleonora ; Lissowska, Jolanta ; Grandis, Jennifer R. ; Weissler, Mark C. ; Tajara, Eloiza H. ; Nunes, Fabio D. ; de Carvalho, Marcos B. ; Thomas, Steve ; Hung, Rayjean J. ; Peters, Wilbert H. M. ; Herrero, Rolando ; Cadoni, Gabriella ; Bueno-de-Mesquita, H. Bas ; Steffen, Annika ; Agudo, Antonio ; Shangina, Oxana ; Xiao, Xiangjun ; Gaborieau, Valerie ; Chabrier, Amelie ; Anantharaman, Devasena ; Boffetta, Paolo ; Amos, Christopher I. ; Mckay, James D. ; Brennan, Paul

• Tipo de documento: Artigo Científico
• Fonte: Nature Genetics; v. 48, n. 12, p. 1544-1550, DEC 2016.
• Citações Web of Science: 44

Resumo

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1{*}1301-HLA-DQA1{*}0103-HLA-DQB1{*}0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. (AU)

• Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular