| Texto completo | |
| Autor(es): Mostrar menos - |
Lesseur, Corina
;
Diergaarde, Brenda
;
Olshan, Andrew F.
;
Wunsch-Filho, Victor
;
Ness, Andrew R.
;
Liu, Geoffrey
;
Lacko, Martin
;
Eluf-Neto, Jose
;
Franceschi, Silvia
;
Lagiou, Pagona
;
Macfarlane, Gary J.
;
Richiardi, Lorenzo
;
Boccia, Stefania
;
Polesel, Jerry
;
Kjaerheim, Kristina
;
Zaridze, David
;
Johanson, Mattias
;
Menezes, Ana M.
;
Curado, Maria Paula
;
Robinson, Max
;
Ahrens, Wolfgang
;
Canova, Cristina
;
Znaor, Ariana
;
Castellsague, Xavier
;
Conway, David I.
;
Holcatova, Ivana
;
Mates, Dana
;
Vidensky, Marta
;
Healy, Claire M.
;
Szeszenia-Dbrowska, Neonila
;
Fabianova, Eleonora
;
Lissowska, Jolanta
;
Grandis, Jennifer R.
;
Weissler, Mark C.
;
Tajara, Eloiza H.
;
Nunes, Fabio D.
;
de Carvalho, Marcos B.
;
Thomas, Steve
;
Hung, Rayjean J.
;
Peters, Wilbert H. M.
;
Herrero, Rolando
;
Cadoni, Gabriella
;
Bueno-de-Mesquita, H. Bas
;
Steffen, Annika
;
Agudo, Antonio
;
Shangina, Oxana
;
Xiao, Xiangjun
;
Gaborieau, Valerie
;
Chabrier, Amelie
;
Anantharaman, Devasena
;
Boffetta, Paolo
;
Amos, Christopher I.
;
Mckay, James D.
;
Brennan, Paul
Número total de Autores: 54
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Nature Genetics; v. 48, n. 12, p. 1544-1550, DEC 2016. |
| Citações Web of Science: | 44 |
| Resumo | |
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1{*}1301-HLA-DQA1{*}0103-HLA-DQB1{*}0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. (AU) | |
| Processo FAPESP: | 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço |
| Beneficiário: | Eloiza Helena Tajara da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço |
| Beneficiário: | Eloiza Helena Tajara da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe |
| Beneficiário: | José Eluf Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |