IMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

Autor(es)

Sader, H. S. ; Reis, A. O. ; Silbert, S. ; Gales, A. C.

• Tipo de documento: Artigo Científico
• Fonte: Clinical Microbiology and Infection; v. 11, n. 1, p. 73-76, Jan. 2005.
• Área do conhecimento: Ciências Biológicas - Microbiologia
• Assunto(s): Infecção hospitalar Anti-infecciosos Bactérias Pseudomonas aeruginosa

Resumo

Pseudomonas aeruginosa isolates (n = 183), collected from bacteraemic patients hospitalised in São Paulo Hospital (Brazil) during 2000-2001, were screened for susceptibility to antimicrobial agents. The polymyxins were the most active compounds (100% susceptibility), followed by amikacin and cefepime (59.0%), meropenem (57.4%), and imipenem and gentamicin (55.2%). Imipenem-resistant isolates were ribotyped and screened for production of metallo--lactamases (MBLs) by PCR with primers for blaIMP, blaVIM and blaSPM. MBL production was detected in 36 isolates (19.7% of the entire collection; 43.9% of the imipenem-resistant isolates) and the MBLs included SPM-1-like (55.6%), VIM-2-like (30.6%) and IMP-1-like (8.3%) enzymes. (AU)

• Processo FAPESP: 01/03349-7 - Caracterizacao molecular de bacteriais multi-resistentes e avaliacao do modo de disseminacao da resistencia bacteriana a antimicrobianos.
• Beneficiário: Eduardo Alexandrino Servolo de Medeiros
• Modalidade de apoio: Auxílio à Pesquisa - Regular