IMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

Sader, H. S.; Reis, A. O.; Silbert, S.; Gales, A. C.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

IMPs, VIMs and SPMs: the diversity of metallo-beta-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

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Author(s):	Sader, H. S. ; Reis, A. O. ; Silbert, S. ; Gales, A. C. Total Authors: 4
Document type:	Journal article
Source:	Clinical Microbiology and Infection; v. 11, n. 1, p. 73-76, Jan. 2005.
Field of knowledge:	Biological Sciences - Microbiology
Abstract
Pseudomonas aeruginosa isolates (n = 183), collected from bacteraemic patients hospitalised in São Paulo Hospital (Brazil) during 2000-2001, were screened for susceptibility to antimicrobial agents. The polymyxins were the most active compounds (100% susceptibility), followed by amikacin and cefepime (59.0%), meropenem (57.4%), and imipenem and gentamicin (55.2%). Imipenem-resistant isolates were ribotyped and screened for production of metallo--lactamases (MBLs) by PCR with primers for blaIMP, blaVIM and blaSPM. MBL production was detected in 36 isolates (19.7% of the entire collection; 43.9% of the imipenem-resistant isolates) and the MBLs included SPM-1-like (55.6%), VIM-2-like (30.6%) and IMP-1-like (8.3%) enzymes. (AU)

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