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ANTIMICROBIAL ACTIVITY OF MAJOR COMPOUNDS FROM ESSENTIAL OILS OVER NOSOCOMIAL BACTERIAL STRAINS

Grant number: 12/10197-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Ary Fernandes Júnior
Grantee:Priscila Martins Leal
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Abstract: Nosocomial diseases are commonly associated with hospitalized people and hospital emergencies due to the occurrence of invasive procedures. Normally, etiologic agents of these diseases are represented by resistent or multi resistent bacteria samples. This way, the search for new antimicrobial compounds is receiving especial attention, including essencial oils or extracts of medicinal plants and some vegetal major compounds. This compounds are often responsible for the biological and antimicrobial properties of the essencial oils. The aim of this study is to verify the inhibitory effects of some major compounds (timol, carvacrol, geraniol, eugenol e terpineol) from different plants over some bacteria strains isolated from hospitalized patients on the "Hospital das Clínicas da FMB/UNESP": Staphylococcus aureus Meticilin Resistent (MRSA), Staphylococcus aureus Meticilin Sensible (MSSA), Pseudomonas aeruginosa and Enterococcus sp . The metodology that will be used is the diluition of antimicrobial compounds in Muller Hinton Agar. Intending to determine if the values of Minimal Inibitory Concentration are bactericidal or bacteriostatic, tests will be made to obtain the survival curves of each specie of essencial oil and to the tested antimicrobians by counting the viable cells over time.