Effect of Treatment With Simvastatin on Bone Microarchitecture of the Femoral Head in an Osteoporosis Animal Model

Autor(es)

Monteiro, Lucas Oliveira ; Macedo, Ana Paula ; Shimano, Roberta Carminati ; Shimano, Antonio Carlos ; Yanagihara, Gabriela Rezende ; Ramos, Junia ; Paulini, Marina Ribeiro ; Tocchini De Figueiredo, Fellipe Augusto ; Gonzaga, Miliane Goncalves ; Mardegan Issa, Joao Paulo

• Tipo de documento: Artigo Científico
• Fonte: MICROSCOPY RESEARCH AND TECHNIQUE; v. 79, n. 8, p. 684-690, AUG 2016.
• Citações Web of Science: 5

Resumo

The objective of this study was to evaluate the microarchitecture and trabecular bone strength at the distal region of the femur, and its biomechanical properties with simvastatin administration with two different doses in ovariectomized (OVX) rats. Ninety rats were divided into six groups to evaluate treatment with the simvastatin drug (n = 15): SH (Sham surgery), SH-5 (5 mg simvastatin), SH-20 (20 mg simvastatin), OVX, OVX-5, and OVX-20. Euthanasia was performed at three different times, five animals per period: 7, 14, and 28 days. The effectiveness of the treatments was evaluated by mechanical testing and histomorphometric analysis of the femurs. The results of analysis by the linear model of mixed effects showed 20 mg of simvastatin results in increased trabecular bone after 14 days (P = 0.039) of ingestion in ovariectomized animals. However, ingestion of 5 mg of simvastatin is able to sensitize the trabecular bone only at 28 days (P = 0.005) of ingestion. In the mechanical tests stiffness improves within 28 days (P = 0.003). Regarding maximum strength, no statistical differences were observed. According to these results, it can be concluded that for a decrease in oral intake, longer treatment times are required. (C) 2016 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 11/13449-0 - Efeito do tratamento com sinvastatina no reparo ósseo de fratura femural em modelo animal de osteoporose
• Beneficiário: João Paulo Mardegan Issa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/11995-0 - Estudo da aplicação de sinvastatina em um modelo experimental para osteoporose
• Beneficiário: Marina Ribeiro Paulini
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica