Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Treatment With Simvastatin on Bone Microarchitecture of the Femoral Head in an Osteoporosis Animal Model

Full text
Author(s):
Monteiro, Lucas Oliveira ; Macedo, Ana Paula ; Shimano, Roberta Carminati ; Shimano, Antonio Carlos ; Yanagihara, Gabriela Rezende ; Ramos, Junia ; Paulini, Marina Ribeiro ; Tocchini De Figueiredo, Fellipe Augusto ; Gonzaga, Miliane Goncalves ; Mardegan Issa, Joao Paulo
Total Authors: 10
Document type: Journal article
Source: MICROSCOPY RESEARCH AND TECHNIQUE; v. 79, n. 8, p. 684-690, AUG 2016.
Web of Science Citations: 5
Abstract

The objective of this study was to evaluate the microarchitecture and trabecular bone strength at the distal region of the femur, and its biomechanical properties with simvastatin administration with two different doses in ovariectomized (OVX) rats. Ninety rats were divided into six groups to evaluate treatment with the simvastatin drug (n = 15): SH (Sham surgery), SH-5 (5 mg simvastatin), SH-20 (20 mg simvastatin), OVX, OVX-5, and OVX-20. Euthanasia was performed at three different times, five animals per period: 7, 14, and 28 days. The effectiveness of the treatments was evaluated by mechanical testing and histomorphometric analysis of the femurs. The results of analysis by the linear model of mixed effects showed 20 mg of simvastatin results in increased trabecular bone after 14 days (P = 0.039) of ingestion in ovariectomized animals. However, ingestion of 5 mg of simvastatin is able to sensitize the trabecular bone only at 28 days (P = 0.005) of ingestion. In the mechanical tests stiffness improves within 28 days (P = 0.003). Regarding maximum strength, no statistical differences were observed. According to these results, it can be concluded that for a decrease in oral intake, longer treatment times are required. (C) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process: 11/13449-0 - Effect of the treatment with sinvastatin on bone healing process of femoral fractures in animal models with osteoporosis
Grantee:João Paulo Mardegan Issa
Support Opportunities: Regular Research Grants
FAPESP's process: 12/11995-0 - Study of the application of simvastatin in an experimental model for osteoporosis
Grantee:Marina Ribeiro Paulini
Support Opportunities: Scholarships in Brazil - Scientific Initiation