Study of the application of simvastatin in an experimental model for osteoporosis

• Grant number: 12/11995-0
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2012
• Effective date (End): November 30, 2013
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal researcher: João Paulo Mardegan Issa
• Grantee: Marina Ribeiro Paulini
• Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Osteoporosis is a metabolic disorder that is very common in females, usually elderly, and that can affect the standard of living of the individual leading to the emergence of bone fractures. Even currently considering the success of drugs that inhibit bone resorption, there is the need for anabolic agents that enhance the new bone formation in people who already had significant bone loss. Thus, numerous products have been studied to evaluate their actions on bone healing process, including drugs that inhibit HMG-CoAredutase (statins), originally used in the treatment of hypercholesterolemia, but with potential pleiotropic beneficial effects on bone healing, especially in individuals suffering from osteoporosis. Thus, the aim of this study is to analyze 30 Wistar rats - Rattus norvegicus albinos, 7-8 weeks old with body weight 220 ± 10 grams, after an oblique fracture in the femur, contained in stainless steel wire, in rats . The animals will be divided into six groups: Ovariectomy (OVX) and SHAM that were fed with liquid Sinvastina at concentrations of 5 and 20 mg / kg / day. The phases of bone repair will be analyzed by the radiographic and histologic methods to determine the effects of simvastatin. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MONTEIRO, LUCAS OLIVEIRA; MACEDO, ANA PAULA; SHIMANO, ROBERTA CARMINATI; SHIMANO, ANTONIO CARLOS; YANAGIHARA, GABRIELA REZENDE; RAMOS, JUNIA; PAULINI, MARINA RIBEIRO; TOCCHINI DE FIGUEIREDO, FELLIPE AUGUSTO; GONZAGA, MILIANE GONCALVES; MARDEGAN ISSA, JOAO PAULO. Effect of Treatment With Simvastatin on Bone Microarchitecture of the Femoral Head in an Osteoporosis Animal Model. MICROSCOPY RESEARCH AND TECHNIQUE, v. 79, n. 8, p. 684-690, AUG 2016. Web of Science Citations: 5.