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The effect of ovariectomy on dental replantation: micro-computed tomography analysis

Grant number: 12/08254-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Sonia Regina Panzarini
Grantee:Heloisa Fonseca Marão
Supervisor abroad: Jeremy J. Mao
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Research place: Columbia University in the City of New York, United States  
Associated to the scholarship:10/12593-8 - The effect of ovariectomy on dental replantation: a histomorphometric and immunohistochemistry analysis in rats, BP.DR


Osteoporosis is an illness that is frequently encountered by dental surgeons in the clinic, and is caused by disequilibrium between processes of bone tissue formation and absorption. With the increasing life expectancy of the global population, more researchers are focusing on geriatrics, in order to provide the population with a healthier aging process. Individuals with osteoporosis are susceptible to both long bone and hip fractures, and dento-alveolar trauma. Considering the shortage of literature in the study of dento-alveolar trauma in individuals with osteoporosis, the aim of this study was to analyze the repair process in immediate dental replanting and its possible association with this systemic alteration (osteoporosis). A well-established experimental model, recommended by the Food and Drug Administration (FDA), was used for this analysis, i.e. ovariectomy (OVX) in rats. The project consists of two experimental groups: group I: sham rats, and group II: OVX rats. The upper right incisor of all animals will be submitted to extraction and immediate tooth replantation. The evaluation will be done by micro computed tomography (¼CT) to analysis and measurement periodontal ligament space, tooth root and bone tissue. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARAO, HELOISA FONSECA; MAO, JEREMY J.; CASATTI, CLAUDIO APARECIDO; COELHO, PAULO G.; ERVOLINO, EDILSON; ZHOU, JIAN; DA SILVA, VANESSA FERREIRA; PANZARINI, SONIA REGINA. Effects of ovariectomy on periodontal tissues following tooth replantation. ARCHIVES OF ORAL BIOLOGY, v. 65, p. 9-16, MAY 2016. Web of Science Citations: 0.

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