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The effect of ovariectomy and hormonal resposition on immediate dental replantation through analysis of interleukin 6 secretion

Grant number: 13/21724-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Sonia Regina Panzarini
Grantee:Vinícius Escórsio Silva
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Oestrogen deficiency is a systematic condition that a dentist can encounter in clinical practice. It appears during menopause and after ovariectomy, and it can cause development of osteopenia and osteoporosis. These conditions affect the maxillary bone and cause bone loss, leading to an unbalance in the processes of bone formation and absorption. Considering the scarcity of literature on tooth replantation associated with this systemic condition and hormone reposition treatment, the aim of this study is to assess the effect of oestrogen deficiency after ovariectomy and hormone reposition treatment with 17-² estradiol following immediate tooth replantation, using the ELISA method for interleukin 6 (IL-6) secretion analysis and radioimmunoassay to test 17-² levels. Female rats will be submitted to oestrous cycle study for a period of 10 days, after which 60 animals with a regular cycle will be selected. The animals will be divided into 3 groups: Group Sham - ovary exposition surgery; Group OVX - ovariectomy; Group OVX/E2 - ovariectomy and hormone reposition. On the 8th day post-surgery subcutaneous pellets with corn oil (Sham and OVX) and 17-² estradiol (OVX/E2) will be implanted in the dorsal region of all animals, and 30 animals will be subjected to exodontia and immediate replantation. On the 53rd day the remaining 30 animals will undergo the same procedure. Hormone reposition therapy with 17-² estradiol will be maintained for a period of 60 days, after which blood will be collected and tested for IL-6 and estradiol.

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