| Texto completo | |
| Autor(es): Mostrar menos - |
Garcia, Michelle L.
;
Pontes, Roberto B.
;
Nishi, Erika E.
;
Ibuki, Flavia K.
;
Oliveira, Vanessa
;
Sawaya, Alexandra C. H.
;
Carvalho, Patricia O.
;
Nogueira, Fernando N.
;
Franco, Maria do Carmo
;
Campos, Ruy R.
;
Oyama, Lila M.
;
Bergamaschi, Cassia T.
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Hypertension; v. 35, n. 2, p. 348-354, FEB 2017. |
| Citações Web of Science: | 15 |
| Resumo | |
Background: Oxidative stress is a key mediator in the maintenance of sympathoexcitation and hypertension in human and experimental models. Green tea is widely known to be potent antioxidant. Objective: We aimed to evaluate the effects of green tea in a model of hypertension. Methods: Hypertension was induced by the nitric oxide synthase inhibitor {[}N-nitro-L-arginine-methyl-ester (L-NAME); 20mg/kg per day, orally, for 2 weeks] in male Wistar rats. After the first week of L-NAME treatment, animals received green tea ad libitum for 1 week. At the end of the treatment period, blood pressure, heart rate, baroreflex sensitivity, renal sympathetic nerve activity, and vascular and systemic oxidative stress were assessed. Results: L-NAME-treated animals exhibited an increase in blood pressure (165 +/- 2 mmHg) compared with control rats (103 +/- 1mmHg) and green tea treatment reduced hypertension (119 +/- 1 mmHg). Hypertensive animals showed a higher renal sympathetic nerve activity (161 +/- 12 spikes/s) than the control group (97 +/- 2 spikes/s), and green tea also decreased this parameter in the hypertensive treated group (125 5 spikes/s). Arterial baroreceptor function and vascular and systemic oxidative stress were improved in hypertensive rats after green tea treatment. Conclusions: Taken together, short-term green tea treatment improved cardiovascular function in a hypertension model characterized by sympathoexcitation, which may be because of its antioxidant properties. (AU) | |
| Processo FAPESP: | 10/09003-4 - Papel da atividade nervosa simpática renal na hipertensão renovascular experimental |
| Beneficiário: | Erika Emy Nishi |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/22522-9 - Papel do nervo simpático renal nas alterações cardiovasculares e renais na hipertensão arterial renovascular |
| Beneficiário: | Ruy Ribeiro de Campos Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |