Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Crystal structure, spectroscopic characterization and antibacterial activities of a silver complex with sulfameter

Texto completo
Autor(es):
Nakahata, Douglas H. ; Lustri, Wilton R. ; Cuin, Alexandre ; Corbi, Pedro P.
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Molecular Structure; v. 1125, p. 609-615, DEC 5 2016.
Citações Web of Science: 7
Resumo

A silver complex with the sulfonamide sulfameter, also known as sulfamethoxydiazine (SMTR), was prepared and characterized. Chemical analyses were consistent with the {[}Ag(C11H11N4O3S)] composition (AgSMTR), while conductivity measurements in DMSO indicated a non-electrolyte behavior of the complex in this solvent. High-resolution ESI(+)-QTOF mass spectrometric experiments revealed the presence of the {[}Ag(C11H11N4O3S)+H](+) and {[}Ag-2(C11H11N4O3S)(2)+H](+) species in solution. Infrared and NMR spectroscopies indicated coordination of the ligand to the metal by the nitrogen atoms of the sulfonamide group and of the pyrimidine ring. The structure of AgSMTR was solved by powder X-ray diffraction technique using the Rietveld method. The solved structure confirms the formation of a dimer, where each silver ion is coordinated by one of the nitrogen atoms of the pyrimidine ring, the nitrogen of the sulfonamide group and by an oxygen atom from the sulfonyl group. An argentophilic interaction of 2.901(1) angstrom is present in this dimeric structure. The AgSMTR complex was assayed over Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains, and it was found that the compound is 8 times more active over the Gram-negative bacteria in DMSO solution, with MIC values in the micromolar range. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 15/25114-4 - Preparação de novos complexos de Ag(I), Cu(II), Pd(II) e Pt(II) à base de sulfonamidas e derivados: estudos de atividade antibacteriana e perspectivas de aplicação em lesões de pele criticamente colonizadas.
Beneficiário:Pedro Paulo Corbi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/20882-3 - Complexos metálicos com sulfametoxidiazina e sulfadimetoxina: síntese, caracterização e aplicações como agentes antimicrobianos para uso tópico
Beneficiário:Douglas Hideki Nakahata
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/09833-0 - Dispositivos de liberação sustentada baseados em biocelulose/complexos metálicos com ligantes bioativos
Beneficiário:Wilton Rogério Lustri
Linha de fomento: Auxílio à Pesquisa - Regular