Crystal structure, spectroscopic characterization and antibacterial activities of a silver complex with sulfameter

Autor(es)

Nakahata, Douglas H. ; Lustri, Wilton R. ; Cuin, Alexandre ; Corbi, Pedro P.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Structure; v. 1125, p. 609-615, DEC 5 2016.
• Citações Web of Science: 7

Resumo

A silver complex with the sulfonamide sulfameter, also known as sulfamethoxydiazine (SMTR), was prepared and characterized. Chemical analyses were consistent with the {[}Ag(C11H11N4O3S)] composition (AgSMTR), while conductivity measurements in DMSO indicated a non-electrolyte behavior of the complex in this solvent. High-resolution ESI(+)-QTOF mass spectrometric experiments revealed the presence of the {[}Ag(C11H11N4O3S)+H](+) and {[}Ag-2(C11H11N4O3S)(2)+H](+) species in solution. Infrared and NMR spectroscopies indicated coordination of the ligand to the metal by the nitrogen atoms of the sulfonamide group and of the pyrimidine ring. The structure of AgSMTR was solved by powder X-ray diffraction technique using the Rietveld method. The solved structure confirms the formation of a dimer, where each silver ion is coordinated by one of the nitrogen atoms of the pyrimidine ring, the nitrogen of the sulfonamide group and by an oxygen atom from the sulfonyl group. An argentophilic interaction of 2.901(1) angstrom is present in this dimeric structure. The AgSMTR complex was assayed over Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains, and it was found that the compound is 8 times more active over the Gram-negative bacteria in DMSO solution, with MIC values in the micromolar range. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 15/09833-0 - Dispositivos de liberação sustentada baseados em biocelulose/complexos metálicos com ligantes bioativos
• Beneficiário: Wilton Rogério Lustri
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/25114-4 - Preparação de novos complexos de Ag(I), Cu(II), Pd(II) e Pt(II) à base de sulfonamidas e derivados: estudos de atividade antibacteriana e perspectivas de aplicação em lesões de pele criticamente colonizadas.
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/20882-3 - Complexos metálicos com sulfametoxidiazina e sulfadimetoxina: síntese, caracterização e aplicações como agentes antimicrobianos para uso tópico
• Beneficiário: Douglas Hideki Nakahata
• Modalidade de apoio: Bolsas no Brasil - Doutorado