BACE1 levels are increased in plasma of Alzheimer's disease patients compared with matched cognitively healthy controls

Autor(es)

Manzine, Patricia Regina ; Souza, Matheus da Silva ; Cominetti, Marcia Regina

• Tipo de documento: Artigo Científico
• Fonte: Personalized Medicine; v. 13, n. 6, p. 531-540, NOV 2016.
• Citações Web of Science: 1

Resumo

Aim: BACE1 is the secretase that acts in A beta production in Alzheimer's disease (AD). Materials \& methods: We investigated mRNA expression in total blood and the levels of plasma protein BACE1 in AD patients compared with cognitively healthy subjects. Probable AD (n = 47) and non-AD control group (n = 32) were evaluated for mRNA expression for BACE1 using reverse transcription-qPCR. A subsample of n = 21 AD and n = 20 non-AD had plasma BACE1 levels analyzed, using ELISA. Results: No differences were found on BACE1 mRNA between groups. However, higher levels of BACE1 were detected in plasma of AD patients. Discussion: Blood-based diagnostic tools are desired to improve AD diagnosis. BACE1 plasma levels could provide an additional diagnostic tool for AD in association with neuropsychological tests. (AU)

• Processo FAPESP: 14/06580-1 - Análise da expressão gênica da BACE1 em sujeitos com Doença de Alzheimer
• Beneficiário: Matheus da Silva Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/06879-4 - Biomarcadores sanguíneos para a Doença de Alzheimer: avaliação da expressão gênica da ADAM10 e de microRNAs
• Beneficiário: Márcia Regina Cominetti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/08654-7 - Biomarcadores sanguíneos para a Doença de Alzheimer: avaliação da expressão gênica da ADAM10 e de micro-RNAs
• Beneficiário: Patricia Regina Manzine Moralles
• Modalidade de apoio: Bolsas no Brasil - Doutorado