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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

BACE1 levels are increased in plasma of Alzheimer's disease patients compared with matched cognitively healthy controls

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Author(s):
Manzine, Patricia Regina ; Souza, Matheus da Silva ; Cominetti, Marcia Regina
Total Authors: 3
Document type: Journal article
Source: Personalized Medicine; v. 13, n. 6, p. 531-540, NOV 2016.
Web of Science Citations: 1
Abstract

Aim: BACE1 is the secretase that acts in A beta production in Alzheimer's disease (AD). Materials \& methods: We investigated mRNA expression in total blood and the levels of plasma protein BACE1 in AD patients compared with cognitively healthy subjects. Probable AD (n = 47) and non-AD control group (n = 32) were evaluated for mRNA expression for BACE1 using reverse transcription-qPCR. A subsample of n = 21 AD and n = 20 non-AD had plasma BACE1 levels analyzed, using ELISA. Results: No differences were found on BACE1 mRNA between groups. However, higher levels of BACE1 were detected in plasma of AD patients. Discussion: Blood-based diagnostic tools are desired to improve AD diagnosis. BACE1 plasma levels could provide an additional diagnostic tool for AD in association with neuropsychological tests. (AU)

FAPESP's process: 12/08654-7 - Blood biomarkers for Alzheimer's Disease: evaluation of ADAM10 gene expression and micro-RNAs
Grantee:Patricia Regina Manzine Moralles
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/06580-1 - Gene expression analysis of BACE1 in patients with Alzheimer's Disease
Grantee:Matheus da Silva Souza
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/06879-4 - Blood biomarkers for Alzheimer's Disease: evaluation of ADAM10 gene expression and microRNAs
Grantee:Márcia Regina Cominetti
Support type: Regular Research Grants