Evaluation of low fluoride toothpaste using primary enamel and a validated pH-cycling model

Autor(es)

de Amoedo Campos Velo, Marilia Mattar ; Machado Tabchoury, Cinthia Pereira ; Romao, Dayse Andrade ; Cury, Jaime Aparecido

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Paediatric Dentistry; v. 26, n. 6, p. 439-447, NOV 2016.
• Citações Web of Science: 2

Resumo

AimTo develop and validate pH-cycling model for primary enamel, which was then used to evaluate the anti-caries potential of fluoride toothpastes. DesignHuman primary enamel slabs were subjected to pH-cycling model for 10days and maintained for 6h in demineralizing solution and 18h in remineralizing solution daily. Twice/day, the slabs were treated. To validate it, the treatments were water or solutions containing 62.5, 125, 250, and 375gF/mL. Commercial toothpastes containing no fluoride, 500, 1100, and 1450gF/g were evaluated. Demineralization was assessed by percentage of surface hardness loss (%SHL) and cross-sectional hardness (S). Fluoride dose-response effect was analysed by quadratic regression and the effects of toothpastes by Tukey's test. ResultsDose-response effect was found between fluoride concentration and %SHL (R-2=0.7047; P<0.01) or S (R-2=0.4465; P<0.01). %SHL and S (meanSD) for the group treated with 500gF/g toothpaste was 36.6 +/- 8.0 and 6298.5 +/- 1221.3, respectively, which were significantly higher than those treated with 1100 (25.2 +/- 8.7; 4565.7 +/- 1122) and 1450gF/g (24.2 +/- 5.2; 2339.1 +/- 879.7) toothpastes. ConclusionThe developed pH-cycling model may be used to evaluate and compare the anti-caries potential of toothpaste formulations with low fluoride concentration because it presents dose-response effects on the reduction of primary enamel demineralization. (AU)

• Processo FAPESP: 12/03105-5 - Validação de modelo de ciclagens de pH para estimar o potencial de produtos fluoretados na redução da desmineralização do esmalte decíduo
• Beneficiário: Marilia Mattar de Amoêdo Campos Velo
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/15251-9 - Validação de modelo de ciclagens de pH para estimar o potencial de produtos fluoretados na redução da desmineralização no esmalte de dente decíduo
• Beneficiário: Cinthia Pereira Machado Tabchoury
• Modalidade de apoio: Auxílio à Pesquisa - Regular