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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of low fluoride toothpaste using primary enamel and a validated pH-cycling model

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Author(s):
de Amoedo Campos Velo, Marilia Mattar ; Machado Tabchoury, Cinthia Pereira ; Romao, Dayse Andrade ; Cury, Jaime Aparecido
Total Authors: 4
Document type: Journal article
Source: International Journal of Paediatric Dentistry; v. 26, n. 6, p. 439-447, NOV 2016.
Web of Science Citations: 2
Abstract

AimTo develop and validate pH-cycling model for primary enamel, which was then used to evaluate the anti-caries potential of fluoride toothpastes. DesignHuman primary enamel slabs were subjected to pH-cycling model for 10days and maintained for 6h in demineralizing solution and 18h in remineralizing solution daily. Twice/day, the slabs were treated. To validate it, the treatments were water or solutions containing 62.5, 125, 250, and 375gF/mL. Commercial toothpastes containing no fluoride, 500, 1100, and 1450gF/g were evaluated. Demineralization was assessed by percentage of surface hardness loss (%SHL) and cross-sectional hardness (S). Fluoride dose-response effect was analysed by quadratic regression and the effects of toothpastes by Tukey's test. ResultsDose-response effect was found between fluoride concentration and %SHL (R-2=0.7047; P<0.01) or S (R-2=0.4465; P<0.01). %SHL and S (meanSD) for the group treated with 500gF/g toothpaste was 36.6 +/- 8.0 and 6298.5 +/- 1221.3, respectively, which were significantly higher than those treated with 1100 (25.2 +/- 8.7; 4565.7 +/- 1122) and 1450gF/g (24.2 +/- 5.2; 2339.1 +/- 879.7) toothpastes. ConclusionThe developed pH-cycling model may be used to evaluate and compare the anti-caries potential of toothpaste formulations with low fluoride concentration because it presents dose-response effects on the reduction of primary enamel demineralization. (AU)

FAPESP's process: 12/03105-5 - Validation of pH cycling model to estimate the potential of fluoridated products in reducing deciduous enamel demineralization
Grantee:Marilia Mattar de Amoêdo Campos Velo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/15251-9 - Validation of a pH-cycling model to estimate the potential of fluoridated products on the reduction of demineralization of enamel of deciduous teeth
Grantee:Cinthia Pereira Machado Tabchoury
Support Opportunities: Regular Research Grants