Cohort profile: the Baependi Heart Study - a family-based, highly admixed cohort study in a rural Brazilian town

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Egan, Kieren J. ; von Schantz, Malcolm ; Negrao, Andre B. ; Santos, Hadassa C. ; Horimoto, Andrea R. V. R. ; Duarte, Nubia E. ; Goncalves, Guilherme C. ; Soler, Julia M. P. ; de Andrade, Mariza ; Lorenzi-Filho, Geraldo ; Vallada, Homero ; Taporoski, Tamara P. ; Pedrazzoli, Mario ; Azambuja, Ana P. ; de Oliveira, Camila M. ; Alvim, Rafael O. ; Krieger, Jose E. ; Pereira, Alexandre C.

• Tipo de documento: Artigo Científico
• Fonte: BMJ OPEN; v. 6, n. 10 2016.
• Citações Web of Science: 5

Resumo

Purpose: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits. Participants: Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Cross-sectional data have been collected for 2239 participants. Findings to date: Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas. Future plans: A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI. (AU)

• Processo FAPESP: 07/58150-7 - Mapeamento genético de fatores de risco cardiovascular na população brasileira: uma abordagem de mapeamento baseada em núcleos familiares: Projeto Corações de Baependi
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 10/51010-8 - Estudos de associacao genomica ampla de fatores de risco associados a doencas cardiovasculares em uma amostra populacional brasileira.
• Beneficiário: Andréa Roseli Vançan Russo Horimoto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/05804-5 - Caracterização fenotípica de ritmos circadianos em indivíduos com diferentes genótipos para polimorfismos nos genes relógio em diferentes regiões do Brasil: ênfase na investigação do gene PER3 e o efeito latitude
• Beneficiário: Mario Pedrazzoli Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular