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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

INVOLVEMENT OF CB1 AND TRPV1 RECEPTORS LOCATED IN THE VENTRAL MEDIAL PREFRONTAL CORTEX IN THE MODULATION OF STRESS COPING BEHAVIOR

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Autor(es):
Sartim, A. G. ; Moreira, F. A. ; Joca, S. R. L.
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: Neuroscience; v. 340, p. 126-134, JAN 6 2017.
Citações Web of Science: 7
Resumo

Cannabinoid type-1 (B-1) and transient receptor potential vanilloid type-1 (TRPV1) receptors may have opposite roles in modulating neural activity and, consequently, in regulating the stress response. These receptors are widely expressed in several brain structures, including the ventral medial prefrontal cortex (vmPFC). The functional consequences of the interaction between CB1 and TRPV1, however, have scarcely been explored. Therefore, we investigated if CB1 and TRPV1 receptors located in the vmPFC would be involved in the behavioral changes induced by the stress of the forced swim test (FST). Rats with cannulae implanted into the vmPFC were given the dual blocker of TRPV1 receptors and fatty acid amide hydrolase (FAAH), Arachidonyl serotonin (AA-5HT, 0.125/0.25/0.5 nmol), TRPV1 antagonist, SB366791 (0.5/1/10 nmol), FAAH inhibitor, URB597 (0.001/0.01/0.1/1 nmol), or vehicle and were submitted to the FST, or to the open-field test. Another group received intra-vmPFC injection of SB366791 or vehicle, followed by a second injection of URB597 or vehicle, and was submitted to the FST. Lastly, a group received intra-vmPFC injection of a CB1 antagonist, in sub-effective dose or vehicle, followed by AA-5HT, SB366791 or vehicle. The results showed that AA-5HT, SB366791 and URB597 significantly reduced the immobility time without changing the locomotor activity. Furthermore, the co-administration of URB597 and SB366791 in sub-effective doses induced an antidepressant-like effect in the FST. Additionally, the antidepressant-like effect of AA-5HT was prevented by the CB1 antagonist. Together, these results suggest that both, CB1 and TRPV1 receptors located in the vmPFC are involved in the behavioral responses to stress, although in opposite ways. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos
Beneficiário:Francisco Silveira Guimaraes
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/00279-5 - Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFMv na modulação de respostas emocionais/comportamentais ao estresse
Beneficiário:Ariandra Guerini Sartim
Linha de fomento: Bolsas no Brasil - Doutorado