On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster

Autor(es)

Cogni, Rodrigo ; Kuczynski, Kate ; Koury, Spencer ; Lavington, Erik ; Behrman, Emily L. ; O'Brien, Katherine R. ; Schmidt, Paul S. ; Eanes, Walter F.

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 7, FEB 21 2017.
• Citações Web of Science: 5

Resumo

Very little information exists for long-term changes in genetic variation in natural populations. Here we take the unique opportunity to compare a set of data for SNPs in 15 metabolic genes from eastern US collections of Drosophila melanogaster that span a large latitudinal range and represent two collections separated by 12 to 13 years. We also expand this to a 22-year interval for the Adh gene and approximately 30 years for the G6pd and Pgd genes. During these intervals, five genes showed a statistically significant change in average SNP allele frequency corrected for latitude. While much remains unchanged, we see five genes where latitudinal clines have been lost or gained and two where the slope significantly changes. The long-term frequency shift towards a southern favored Adh S allele reported in Australia populations is not observed in the eastern US over a period of 21 years. There is no general pattern of southern-favored or northern-favored alleles increasing in frequency across the genes. This observation points to the fluid nature of some allelic variation over this time period and the action of selective responses or migration that may be more regional than uniformly imposed across the cline. (AU)

• Processo FAPESP: 13/25991-0 - Ecologia genômica de insetos: adaptações ao clima e evolução de interações ecológicas
• Beneficiário: Rodrigo Cogni
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores