Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

Autor(es):Mostrar menos -

Nicacio, Karen J. ; Ioca, Laura P. ; Froes, Adriana M. ; Leomil, Luciana ; Appolinario, Luciana R. ; Thompson, Christiane C. ; Thompson, Fabiano L. ; Ferreira, Antonio G. ; Williams, David E. ; Andersen, Raymond J. ; Eustaquio, Alessandra S. ; Berlinck, Roberto G. S.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 80, n. 2, p. 235-240, FEB 2017.
• Citações Web of Science: 20

Resumo

Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and aplysinamisine II (7), from cultures of the marine bacterium Pseudovibrio denitrificans Ab134, isolated from tissues of the marine sponge Arenosclera brasiliensis. These results unambiguously demonstrate for the first time that bromotyrosine-derived alkaloids that were previously isolated only from Verongida sponges can be biosynthesized by a marine bacterium. (AU)

• Processo FAPESP: 16/05133-7 - Estudo do metabolismo de micro-organismos do ambiente marinho: perfil químico e biossíntese
• Beneficiário: Laura Pavan Ióca
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/50228-8 - Componentes da biodiversidade, e seus caracteres metabólicos, de ilhas do Brasil: uma abordagem integrada
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático