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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

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Nicacio, Karen J. ; Ioca, Laura P. ; Froes, Adriana M. ; Leomil, Luciana ; Appolinario, Luciana R. ; Thompson, Christiane C. ; Thompson, Fabiano L. ; Ferreira, Antonio G. ; Williams, David E. ; Andersen, Raymond J. ; Eustaquio, Alessandra S. ; Berlinck, Roberto G. S.
Total Authors: 12
Document type: Journal article
Source: Journal of Natural Products; v. 80, n. 2, p. 235-240, FEB 2017.
Web of Science Citations: 20

Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and aplysinamisine II (7), from cultures of the marine bacterium Pseudovibrio denitrificans Ab134, isolated from tissues of the marine sponge Arenosclera brasiliensis. These results unambiguously demonstrate for the first time that bromotyrosine-derived alkaloids that were previously isolated only from Verongida sponges can be biosynthesized by a marine bacterium. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 16/05133-7 - Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis
Grantee:Laura Pavan Ióca
Support type: Scholarships in Brazil - Doctorate