Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis

• Grant number: 16/05133-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2016
• End date: December 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Laura Pavan Ióca
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated scholarship(s): 18/10742-8 - The role of a nonribosomal peptide in promoting swarming in Pseudovibrio brasiliensis Ab134 and related bacteria, BE.EP.DR

Abstract

The present project seeks to expand the knowledge of the enzimatic machinary of three unique secondary metabolic class, including the genome mining of the marine bacterium Pseudovibrio brasiliensis Ab134, as well as the search for the gene clusters responsible for the biosynthesis of the ±-nitropyrones, isopyrophen e naphthoquinoneimine, in the genome of the marine-erived fungus Aspergillus sp. DLM38, roussoelatide in Roussoella sp. DLM33, and phomactins into the genome of Biatriospora sp. CBMAI 1333.

Scientific publications

(12)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

KAHLERT, LUKAS; BERNARDI, DARLON; HAUSER, MAURICE; IOCA, LAURA P.; BERLINCK, ROBERTO G. S.; SKELLAM, ELIZABETH J.; COX, RUSSELL J.. Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. CHEMISTRY-A EUROPEAN JOURNAL, v. 27, n. 46, p. 11895-11903, AUG 16 2021. (16/05133-7, 18/10742-8, 16/21341-9, 13/50228-8, 20/11691-8, 19/17721-9)

TONON, LUCIANE A. CHIMETTO; RUA, CINTIA; CRNKOVIC, CAMILA M.; BERNARDI, I, DARLON; JUNIOR, OSMINDO R. PIRES; HADDAD, CELIO F. B.; PEDROSA, CAROLINADA S. G.; SOUZA, LETICIA R. Q.; REHEN, STEVENS K.; DE AZEVEDO, GUSTAVO P. R.; et al. Microbiome associated with the tetrodotoxin-bearing anuran Brachycephalus pitanga. Toxicon, v. 203, p. 139-146, NOV 2021. (13/50741-7, 16/14375-4, 16/05133-7, 17/06014-4, 13/50228-8, 16/21341-9, 19/00447-1)

BERLINCK, ROBERTO G. S.; CRNKOVIC, CAMILA M.; GUBIANI, JULIANA R.; BERNARDI, DARLON I.; IOCA, LAURA P.; QUINTANA-BULLA, JAIRO I.. The isolation of water-soluble natural products - challenges, strategies and perspectives. NATURAL PRODUCT REPORTS, OCT 2021. (13/50228-8, 16/16033-3, 19/00447-1, 20/11691-8, 16/05133-7, 17/06014-4, 16/21341-9, 18/10742-8)

DE AMORIM, MARCELO R.; BARBOSA, CAMILA DE S.; PAZ, TIAGO A.; IOCA, LAURA P.; NICACIO, KAREN J.; DE OLIVEIRA, LUCIANNE F. P.; GOULART, MIRIAN O.; PAULINO, JULIA M.; DA CRUZ, MATEUS O.; FERREIRA, ANTONIO G.; et al. Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.. Journal of Natural Products, v. 86, n. 6, p. 11-pg., 2023-06-08. (19/17721-9, 16/05133-7, 15/01017-0, 20/12904-5, 20/01229-5)

IOCA, LAURA P.; NICACIO, KAREN J.; BERLINCK, ROBERTO G. S.. Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 998-1031, MAY 2018. (16/05133-7, 13/50228-8)

KAHLERT, LUKAS; BERNARDI, DARLON; HAUSER, MAURICE; IOCA, LAURA P.; BERLINCK, ROBERTO G. S.; SKELLAM, ELIZABETH J.; COX, RUSSELL J.. Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. CHEMISTRY-A EUROPEAN JOURNAL, JUN 2021. (19/17721-9, 18/10742-8, 16/05133-7, 16/21341-9, 13/50228-8, 20/11691-8)

IOCA, LAURA P.; DAI, YITAO; KUNAKOM, SYLVIA; DIAZ-ESPINOSA, JENNIFER; KRUNIC, ALEKSEJ; CRNKOVIC, CAMILA M.; ORJALA, JIMMY; SANCHEZ, LAURA M.; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S.; et al. A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges{*}{*}. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 60, n. 29, p. 15891-15898, JUL 12 2021. (15/01017-0, 16/05133-7, 18/10742-8)

RODRIGUES-COSTA, FERNANDA; SLIVINSKI, JULIANO; IOCA, LAURA P.; BERTONHA, ARIANE F.; DE FELICIO, RAFAEL; DA CUNHA, MARCOS GUILHERME; DA MATA MADEIRA, PAULO VINICIUS; CAUZ, ANA C. G.; TRINDADE, DANIEL MARAGNO; FREIRE, VITOR F.; et al. Merulinic acid C overcomes gentamicin resistance in Enterococcus faecium. BIOORGANIC CHEMISTRY, v. 100, JUL 2020. (16/05133-7, 13/50228-8, 11/52067-6, 17/12436-9, 15/19906-5, 14/11980-9)

BERTONHA, ARIANE F.; WILLIAMS, DAVID E.; NICACIO, KAREN J.; DE AMORIM, MARCELO R.; SCHOELLHORN, SYDNEY M.; AGUIAR, ANNA CAROLINE C.; VALDES, TALITA ALVARENGA; MENDES, GIOVANA ROSSI; MOURA, IGOR M. R.; MICHALISKI, LAMONIELLI F.; et al. NMR Analysis and Assignment of a Biosynthesis Gene Cluster for Trichokonins VI and VIII, Antiplasmodial Large Peptaibols Produced by a Trichoderma sp. Fungus. ACS OMEGA, v. 10, n. 41, p. 15-pg., 2025-10-10. (23/17676-9, 13/07600-3, 21/03977-1, 21/07343-7, 20/01229-5, 15/18192-9, 24/04949-0, 15/01017-0, 24/04805-8, 22/07831-4, 22/01063-5, 18/10742-8, 19/07894-3, 19/17721-9, 16/05133-7)

NICACIO, KAREN J.; IOCA, LAURA P.; FROES, ADRIANA M.; LEOMIL, LUCIANA; APPOLINARIO, LUCIANA R.; THOMPSON, CHRISTIANE C.; THOMPSON, FABIANO L.; FERREIRA, ANTONIO G.; WILLIAMS, DAVID E.; ANDERSEN, RAYMOND J.; et al. Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges. Journal of Natural Products, v. 80, n. 2, p. 235-240, FEB 2017. (16/05133-7, 13/50228-8)

MICHALISKI, LAMONIELLI F.; IOCA, LAURA P.; OLIVEIRA, LEANDRO S.; CRNKOVIC, CAMILA M.; TAKAKI, MIRELLE; FREIRE, VITOR F.; BERLINCK, ROBERTO G. S.. Improvement of Targeted Fungi Secondary Metabolite Production Using a Systematic Experimental Design and Chemometrics Analysis. METHODS AND PROTOCOLS, v. 6, n. 5, p. 18-pg., 2023-10-01. (19/07894-3, 15/01017-0, 22/07831-4, 16/05133-7, 15/14114-3, 19/17721-9, 18/10742-8, 18/03679-8, 19/00447-1)

DAI, YITAO; LOURENZON, VITOR; IOCA, LAURA P.; AL-SMADI, DUA; ARNOLD, LYDIA; MCINTIRE, IAN; BERLINCK, ROBERTO G. S.; EUSTAQUIO, ALESSANDRA S.. Pseudovibriamides from Pseudovibrio marine sponge bacteria promote flagellar motility via transcriptional modulation. MBIO, v. 16, n. 2, p. 19-pg., 2024-12-27. (18/10742-8, 16/05133-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

IÓCA, Laura Pavan. Discovery and biosynthetic studies of non-ribosomal peptides involved in Pseudovibrio brasiliensis Ab134 motility. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.