Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis

• Grant number: 16/05133-7
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): June 01, 2016
• Effective date (End): December 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal researcher: Roberto Gomes de Souza Berlinck
• Grantee: Laura Pavan Ióca
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated scholarship(s): 18/10742-8 - The role of a nonribosomal peptide in promoting swarming in Pseudovibrio brasiliensis Ab134 and related bacteria, BE.EP.DR

Abstract

The present project seeks to expand the knowledge of the enzimatic machinary of three unique secondary metabolic class, including the genome mining of the marine bacterium Pseudovibrio brasiliensis Ab134, as well as the search for the gene clusters responsible for the biosynthesis of the ±-nitropyrones, isopyrophen e naphthoquinoneimine, in the genome of the marine-erived fungus Aspergillus sp. DLM38, roussoelatide in Roussoella sp. DLM33, and phomactins into the genome of Biatriospora sp. CBMAI 1333.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES-COSTA, FERNANDA; SLIVINSKI, JULIANO; IOCA, LAURA P.; BERTONHA, ARIANE F.; DE FELICIO, RAFAEL; DA CUNHA, MARCOS GUILHERME; DA MATA MADEIRA, PAULO VINICIUS; CAUZ, ANA C. G.; TRINDADE, DANIEL MARAGNO; FREIRE, VITOR F.; ROPKE, CRISTINA DISLICH; GALES, ANA; BROCCHI, MARCELO; FERREIRA, ANTONIO G.; GUEIROS-FILHO, FREDERICO; BARBOSA TRIVELLA, DANIELA BARRETTO; BERLINCK, ROBERTO G. S.; DESSEN, ANDREA. Merulinic acid C overcomes gentamicin resistance in Enterococcus faecium. BIOORGANIC CHEMISTRY, v. 100, JUL 2020. Web of Science Citations: 0.

IOCA, LAURA P.; NICACIO, KAREN J.; BERLINCK, ROBERTO G. S. Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 998-1031, MAY 2018. Web of Science Citations: 2.

NICACIO, KAREN J.; IOCA, LAURA P.; FROES, ADRIANA M.; LEOMIL, LUCIANA; APPOLINARIO, LUCIANA R.; THOMPSON, CHRISTIANE C.; THOMPSON, FABIANO L.; FERREIRA, ANTONIO G.; WILLIAMS, DAVID E.; ANDERSEN, RAYMOND J.; EUSTAQUIO, ALESSANDRA S.; BERLINCK, ROBERTO G. S. Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges. Journal of Natural Products, v. 80, n. 2, p. 235-240, FEB 2017. Web of Science Citations: 20.