Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis
| Grant number: | 18/10742-8 |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| Effective date (Start): | August 01, 2018 |
| Effective date (End): | July 31, 2019 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Principal Investigator: | Roberto Gomes de Souza Berlinck |
| Grantee: | Laura Pavan Ióca |
| Supervisor abroad: | Alessandra S Eustaquio |
| Home Institution: | Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
| Local de pesquisa : | University of Illinois at Chicago (UIC), United States |
| Associated to the scholarship: | 16/05133-7 - Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis, BP.DR |
Abstract Genome analyses of the alpha-proteobacterium Pseudovibrio brasiliensis Ab134, a symbiont of the sponge Arenosclera brasiliensis, showed the presence of at least six biosynthetic gene clusters (BGCs) encoding the biosynthesis of secondary metabolites. Among these, a nonribosomal peptide synthetase (NRPS) BCG was shown to be involved in the swarming capability of this bacterial strain. The NRPS BGC is also found in Pseudomonas species, which belong to the class of gamma-proteobacteria, and which are known pathogens of plants and animals. The ability to swarm may facilitate symbiotic or pathogenic associations with host tissues. However, detailed knowledge about the mechanisms of this motility behavior is lacking. This project aims to study the role and mechanism of the nonribosomal peptide in promoting swarming by Pseudovibrio and Pseudomonas species, expanding our knowledge about the conserved mechanisms that proteobacteria employ to coordinate swarming and to colonize eukaryotic hosts. | |