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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The isolation of water-soluble natural products - challenges, strategies and perspectives

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Author(s):
Berlinck, Roberto G. S. [1] ; Crnkovic, Camila M. [2] ; Gubiani, Juliana R. [1] ; Bernardi, Darlon I. [1] ; Ioca, Laura P. [1] ; Quintana-Bulla, Jairo I. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-13560970 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: NATURAL PRODUCT REPORTS; OCT 2021.
Web of Science Citations: 0
Abstract

Covering period: up to 2019 Water-soluble natural products constitute a relevant group of secondary metabolites notably known for presenting potent biological activities. Examples are aminoglycosides, beta-lactam antibiotics, saponins of both terrestrial and marine origin, and marine toxins. Although extensively investigated in the past, particularly during the golden age of antibiotics, hydrophilic fractions have been less scrutinized during the last few decades. This review addresses the possible reasons on why water-soluble metabolites are now under investigated and describes approaches and strategies for the isolation of these natural compounds. It presents examples of several classes of hydrosoluble natural products and how they have been isolated. Novel stationary phases and chromatography techniques are also reviewed, providing a perspective towards a renaissance in the investigation of water-soluble natural products. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 16/16033-3 - Bromopyrrole alkaloids from the Cultured Microbiome of the Marine Sponge Tedania brasiliensis
Grantee:Jairo Iván Quintana Bulla
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/00447-1 - Improving and diversifying the production and investigating the biosynthesis of phomactins by the cultured fungus Biatriospora sp. CBMAI 1333
Grantee:Camila Manoel Crnkovic
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 20/11691-8 - Biosynthesis of roussoellatide, a polyketide isolated from the fungus Roussoella sp. DLM-33
Grantee:Darlon Irineu Bernardi
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 16/05133-7 - Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis
Grantee:Laura Pavan Ióca
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer
Grantee:Juliana Regina Gubiani
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/21341-9 - Hydrophilic and bioactive secondary metabolites produced by filamentous fungi
Grantee:Darlon Irineu Bernardi
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/10742-8 - The role of a nonribosomal peptide in promoting swarming in Pseudovibrio brasiliensis Ab134 and related bacteria
Grantee:Laura Pavan Ióca
Support Opportunities: Scholarships abroad - Research Internship - Doctorate