| Full text | |
| Author(s): |
Berlinck, Roberto G. S.
[1]
;
Crnkovic, Camila M.
[2]
;
Gubiani, Juliana R.
[1]
;
Bernardi, Darlon I.
[1]
;
Ioca, Laura P.
[1]
;
Quintana-Bulla, Jairo I.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-13560970 Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | NATURAL PRODUCT REPORTS; OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Covering period: up to 2019 Water-soluble natural products constitute a relevant group of secondary metabolites notably known for presenting potent biological activities. Examples are aminoglycosides, beta-lactam antibiotics, saponins of both terrestrial and marine origin, and marine toxins. Although extensively investigated in the past, particularly during the golden age of antibiotics, hydrophilic fractions have been less scrutinized during the last few decades. This review addresses the possible reasons on why water-soluble metabolites are now under investigated and describes approaches and strategies for the isolation of these natural compounds. It presents examples of several classes of hydrosoluble natural products and how they have been isolated. Novel stationary phases and chromatography techniques are also reviewed, providing a perspective towards a renaissance in the investigation of water-soluble natural products. (AU) | |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 16/16033-3 - Bromopyrrole alkaloids from the Cultured Microbiome of the Marine Sponge Tedania brasiliensis |
| Grantee: | Jairo Iván Quintana Bulla |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/00447-1 - Improving and diversifying the production and investigating the biosynthesis of phomactins by the cultured fungus Biatriospora sp. CBMAI 1333 |
| Grantee: | Camila Manoel Crnkovic |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/11691-8 - Biosynthesis of roussoellatide, a polyketide isolated from the fungus Roussoella sp. DLM-33 |
| Grantee: | Darlon Irineu Bernardi |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 16/05133-7 - Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis |
| Grantee: | Laura Pavan Ióca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer |
| Grantee: | Juliana Regina Gubiani |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/21341-9 - Hydrophilic and bioactive secondary metabolites produced by filamentous fungi |
| Grantee: | Darlon Irineu Bernardi |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 18/10742-8 - The role of a nonribosomal peptide in promoting swarming in Pseudovibrio brasiliensis Ab134 and related bacteria |
| Grantee: | Laura Pavan Ióca |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |