Investigation of biosynthetic routes of polyketides and alkaloids from marine microorganisms

• Grant number: 10/05100-5
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): November 01, 2010
• Effective date (End): October 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Eli Fernando Pimenta
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 05/60175-2 - Discovery and development of potential chemotherapeutic agents based on marine invertebrates and associated micro-organisms, AP.BTA.TEM

Abstract

Merine-derived fungi are considered a particularly important group as a source of bioactive natural products. Among the natural products isolated from these fungi, polyketides constitute the largest number of metabolites, which often have biological activities. The objective of this project is to investigate biosynthetic routes of polyketides and alkaloids which have already been isolated (and identified) from marine-derived fungi. Biosynthesis studies of metabolites previously isolated and identified will be carried out using incorporation experiments with 13C labeled precursors for alkaloids and polyketides. The results of the experiments of incorporation will be analyzed by NMR - 13C and high resolution mass spectrometry. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROMMINGER, STELAMAR; PIMENTA, ELI F.; NASCIMENTO, EDUARDO S.; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S. Biosynthesis of Two Dihydropyrrole-Polyketides from a Marine-Derived Penicillium citrinum. Journal of the Brazilian Chemical Society, v. 23, n. 10, p. 1783-1788, OCT 2012. Web of Science Citations: 7.