Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds

Autor(es)

Silva, Marcio S.

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 22, n. 2 FEB 2017.
• Citações Web of Science: 19

Resumo

Nuclear magnetic resonance (NMR) is a powerful tool for the elucidation of chemical structure and chiral recognition. In the last decade, the number of probes, media, and experiments to analyze chiral environments has rapidly increased. The evaluation of chiral molecules and systems has become a routine task in almost all NMR laboratories, allowing for the determination of molecular connectivities and the construction of spatial relationships. Among the features that improve the chiral recognition abilities by NMR is the application of different nuclei. The simplicity of the multinuclear NMR spectra relative to H-1, the minimal influence of the experimental conditions, and the larger shift dispersion make these nuclei especially suitable for NMR analysis. Herein, the recent advances in multinuclear (F-19, P-31, C-13, and Se-77) NMR spectroscopy for chiral recognition of organic compounds are presented. The review describes new chiral derivatizing agents and chiral solvating agents used for stereodiscrimination and the assignment of the absolute configuration of small organic compounds. (AU)

• Processo FAPESP: 14/23362-8 - Uso de técnicas não clássicas de ressonância magnética nuclear no planejamento e discriminação quiral de processos biocatalíticos
• Beneficiário: Márcio Santos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular