Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Can positron emission mammography help to identify clinically significant breast cancer in women with suspicious calcifications on mammography?

Texto completo
Autor(es):
Bitencourt, Almir G. V. ; Lima, Eduardo N. P. ; Macedo, Bruna R. C. ; Conrado, Jorge L. F. A. ; Marques, Elvira F. ; Chojniak, Rubens
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: EUROPEAN RADIOLOGY; v. 27, n. 5, p. 1893-1900, MAY 2017.
Citações Web of Science: 5
Resumo

To evaluate the diagnostic accuracy of positron emission mammography (PEM) for identifying malignant lesions in patients with suspicious microcalcifications detected on mammography. A prospective, single-centre study that evaluated 40 patients with suspicious calcifications at mammography and indication for percutaneous or surgical biopsy, with mean age of 56.4 years (range: 28-81 years). Patients who agreed to participate in the study underwent PEM with 18F-fluorodeoxyglucose before the final histological evaluation. PEM findings were compared with mammography and histological findings. Most calcifications (n = 34; 85.0 %) were classified as BIRADS 4. On histology, there were 25 (62.5 %) benign and 15 (37.5 %) malignant lesions, including 11 (27.5 %) ductal carcinoma in situ (DCIS) and 4 (10 %) invasive carcinomas. On subjective analysis, PEM was positive in 15 cases (37.5 %) and most of these cases (n = 14; 93.3 %) were confirmed as malignant on histology. There was one false-positive result, which corresponded to a fibroadenoma, and one false negative, which corresponded to an intermediate-grade DCIS. PEM had a sensitivity of 93.3 %, specificity of 96.0 % and accuracy of 95 %. PEM was able to identify all invasive carcinomas and high-grade DCIS (nuclear grade 3) in the presented sample, suggesting that this method may be useful for further evaluation of patients with suspected microcalcifications. aEuro cent Many patients with suspicious microcalcifications at mammography have benign results at biopsy. aEuro cent PEM may help to identify invasive carcinomas and high-grade DCIS. aEuro cent Management of patients with suspicious calcifications can be improved. (AU)

Processo FAPESP: 13/09907-9 - Mamografia por emissão de pósitrons (PEM) na avaliação de pacientes com microcalcificações suspeitas
Beneficiário:Eduardo Nóbrega Pereira Lima
Modalidade de apoio: Auxílio à Pesquisa - Regular