Technical aspects and challenges of colorimetric detection with microfluidic paper-based analytical devices (mu PADs) - A review

Autor(es)

Morbioli, Giorgio Gianini ; Mazzu-Nascimento, Thiago ; Stockton, Amanda M. ; Carrilho, Emanuel

• Tipo de documento: Artigo de Revisão
• Fonte: Analytica Chimica Acta; v. 970, p. 1-22, JUN 1 2017.
• Citações Web of Science: 77

Resumo

Paper-based devices are a leading alternative among the main analytical tools for point-of-care testing, due to their portability, low-cost, and ease-of-use. Colorimetric readouts are the most common method of detection in these microfluidic devices, enabling qualitative, semi-quantitative and fully quantitative analysis of multiple analytes. There is a multitude of ways to obtain a colorimetric output in such devices, including nanoparticles, dyes, redox and pH indicators, and each has unique drawbacks and benefits. There are also multiple variables that impact the analysis of colorimetric reactions in microfluidic paperbased systems, including color homogeneity, image capture methods, and the data handling itself. Here, we present a critical review of recent developments and challenges of colorimetric detection on microfluidic paper-based analytical devices (mu PADs), and present thoughts and insights towards future perspectives in the area to improve the use of colorimetric readouts in conjunction with mu PADs. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/13997-8 - Plataformas em papel para detecção não invasiva de biomarcadores tumorais e para cultivo de células neoplásicas
• Beneficiário: Thiago Mazzu Do Nascimento
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 08/57805-2 - Instituto de Bioanalítica
• Beneficiário: Lauro Tatsuo Kubota
• Modalidade de apoio: Auxílio à Pesquisa - Temático