Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice

Autor(es)

Spindola, Humberto M. ; Grando, Rogerio ; Figueiredo, Mariana C. ; Basting, Rosana ; Queiroz, N. C. A. ; de Fatima, Angelo ; de Carvalho, Joao E. ; Wang, Zaijie J. ; Foglio, M. A.

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmacology; v. 804, p. 68-77, JUN 5 2017.
• Citações Web of Science: 2

Resumo

Pterodon genus fruits are commercially available at the Brazilian medicinal market used in folk medicine due to their anti-inflammatory, analgesic, and anti-rheumatic effects. Previous studies demonstrated that furanditerpenes possessing vouacapan skeleton, isolated from Pterodon genus, possess expressive antinociceptive activities, with promising moiety for the development of new analgesic products. The antinociceptive properties of compounds 6 alpha,7/beta-6 alpha-hidroxivouacapan-7 beta-17 beta-lactone (HVL) and 6 alpha-oxovouacapan-7 beta-17 beta-lactone (OVL), semi-synthetic analogues of furanditerpenes previously reported as analgesic agents were evaluated on animal experimental models (Spindola et al., 2010, 2011). The chemical-induced pain methods used in the present work, demonstrated for the first time that both compounds HVL and OVL have potential as important templates for the development of chronic pain control drugs. The main findings of this work were that both compounds were: effective in the writhing test; reduced paw edema in the carrageenan test; effective in the inflammatory phase of the formalin test corroborating their activity against inflammatory pain conditions; effective on reducing pain through the stimulation of vanilloid receptors sensible to capsaicin (an important pathway for chronic pain maintenance); reduced the pain stimulus caused by PGE(2) injection (a pathway involved in chronic pain hypersensitivity); effective on decreasing mechanical allodynia in the CFA-model, demonstrating their potential use against chronic pain disorders. (AU)

• Processo FAPESP: 10/09287-2 - Caracterização da atividade antinociceptiva de moléculas bioativas: estudos pré-clínicos para o desenvolvimento de novos medicamentos analgésicos.
• Beneficiário: Humberto Moreira Spindola
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/19661-4 - Pterodon pubescens Benth.: avaliação do efeito sinérgico dos vouocapanos e geranilgeranil sobre a atividade antinociceptiva, estudos farmacocinéticos e toxicológicos pré-clínicos
• Beneficiário: Mary Ann Foglio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/03652-6 - Caracterização da atividade antinociceptiva neuropática de moléculas bioativas
• Beneficiário: Humberto Moreira Spindola
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado