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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice

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Author(s):
Spindola, Humberto M. ; Grando, Rogerio ; Figueiredo, Mariana C. ; Basting, Rosana ; Queiroz, N. C. A. ; de Fatima, Angelo ; de Carvalho, Joao E. ; Wang, Zaijie J. ; Foglio, M. A.
Total Authors: 9
Document type: Journal article
Source: European Journal of Pharmacology; v. 804, p. 68-77, JUN 5 2017.
Web of Science Citations: 2
Abstract

Pterodon genus fruits are commercially available at the Brazilian medicinal market used in folk medicine due to their anti-inflammatory, analgesic, and anti-rheumatic effects. Previous studies demonstrated that furanditerpenes possessing vouacapan skeleton, isolated from Pterodon genus, possess expressive antinociceptive activities, with promising moiety for the development of new analgesic products. The antinociceptive properties of compounds 6 alpha,7/beta-6 alpha-hidroxivouacapan-7 beta-17 beta-lactone (HVL) and 6 alpha-oxovouacapan-7 beta-17 beta-lactone (OVL), semi-synthetic analogues of furanditerpenes previously reported as analgesic agents were evaluated on animal experimental models (Spindola et al., 2010, 2011). The chemical-induced pain methods used in the present work, demonstrated for the first time that both compounds HVL and OVL have potential as important templates for the development of chronic pain control drugs. The main findings of this work were that both compounds were: effective in the writhing test; reduced paw edema in the carrageenan test; effective in the inflammatory phase of the formalin test corroborating their activity against inflammatory pain conditions; effective on reducing pain through the stimulation of vanilloid receptors sensible to capsaicin (an important pathway for chronic pain maintenance); reduced the pain stimulus caused by PGE(2) injection (a pathway involved in chronic pain hypersensitivity); effective on decreasing mechanical allodynia in the CFA-model, demonstrating their potential use against chronic pain disorders. (AU)

FAPESP's process: 12/03652-6 - Characterization of the neurophatic antinociceptive activity of bioactive molecules
Grantee:Humberto Moreira Spindola
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 12/19661-4 - Vouacapans and geranilgeraniol synergic effect evaluation on nociceptive pain, Pharmacokinetic and preclinical toxicological studies
Grantee:Mary Ann Foglio
Support type: Regular Research Grants
FAPESP's process: 10/09287-2 - Characterization of antinociceptive activity of bioactive molecules: preclinical studies for the development of new analgesics
Grantee:Humberto Moreira Spindola
Support type: Scholarships in Brazil - Post-Doctorate