| Texto completo | |
| Autor(es): |
Trarbach, Ericka B.
;
Jorge, Alexander A.
;
Duarte, Felipe H.
;
Bronstein, Marcello D.
;
Jallad, Raquel S.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Pituitary; v. 20, n. 3, p. 319-324, JUN 2017. |
| Citações Web of Science: | 0 |
| Resumo | |
Purpose Suppressor of cytokine signaling 2 (SOCS2) is a STAT5b-regulated gene and one of its functions is to influence growth and development through negative regulatory effects on GH/IGF-1 pathway. So, we evaluate the potential influence of SOCS2 single nucleotide polymorphisms (SNPs) on clinical and laboratorial characteristics of a large cohort of Brazilian patients with acromegaly. Methods Four SOCS2 SNPs (rs3782415, rs3816997, rs3825199 and rs11107116) were selected and genotyped by real-time PCR using specific Taqman probe assays. A total of 186 patients (116 women, age range 26-88 years) were evaluated. Results No association of SOCS2 genotypes was observed with none of the following clinical and laboratorial characteristics: age, sex, body mass index, comorbidities, basal GH, oral glucose tolerance test GH nadir, IGF-I, ULNRIGF-I. Conclusion Despite of the key role of SOCS2 in the regulation of GH receptor signaling, we did not find any significant association between SOCS2 polymorphisms and acromegaly. (AU) | |
| Processo FAPESP: | 10/11718-1 - Polimorfismos em genes do receptor de gh (ghr) e do igfbp3 em acromegalia: correlação com quadro clínico/laboratorial e com resposta terapêutica |
| Beneficiário: | Marcello Delano Bronstein |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |