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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

SOCS2 polymorphisms are not associated with clinical and biochemical phenotypes in acromegalic patients

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Trarbach, Ericka B. ; Jorge, Alexander A. ; Duarte, Felipe H. ; Bronstein, Marcello D. ; Jallad, Raquel S.
Total Authors: 5
Document type: Journal article
Source: Pituitary; v. 20, n. 3, p. 319-324, JUN 2017.
Web of Science Citations: 0

Purpose Suppressor of cytokine signaling 2 (SOCS2) is a STAT5b-regulated gene and one of its functions is to influence growth and development through negative regulatory effects on GH/IGF-1 pathway. So, we evaluate the potential influence of SOCS2 single nucleotide polymorphisms (SNPs) on clinical and laboratorial characteristics of a large cohort of Brazilian patients with acromegaly. Methods Four SOCS2 SNPs (rs3782415, rs3816997, rs3825199 and rs11107116) were selected and genotyped by real-time PCR using specific Taqman probe assays. A total of 186 patients (116 women, age range 26-88 years) were evaluated. Results No association of SOCS2 genotypes was observed with none of the following clinical and laboratorial characteristics: age, sex, body mass index, comorbidities, basal GH, oral glucose tolerance test GH nadir, IGF-I, ULNRIGF-I. Conclusion Despite of the key role of SOCS2 in the regulation of GH receptor signaling, we did not find any significant association between SOCS2 polymorphisms and acromegaly. (AU)

FAPESP's process: 10/11718-1 - Polymorphisms in genes of GH receptor (GHR) and IGFBP3 in acromegaly: correlation with clinical / laboratory parameters and response to therapy
Grantee:Marcello Delano Bronstein
Support type: Regular Research Grants