Electrochemical Sensor-Based Ruthenium Nanoparticles on Reduced Graphene Oxide for the Simultaneous Determination of Ethinylestradiol and Amoxicillin

Autor(es)

Prado, Thiago M. ; Cincotto, Fernando H. ; Moraes, Fernando C. ; Machado, Sergio A. S.

• Tipo de documento: Artigo Científico
• Fonte: Electroanalysis; v. 29, n. 5, p. 1278-1285, MAY 2017.
• Citações Web of Science: 8

Resumo

The composite material of reduced graphene and Ru nanoparticles (rGO/RuNP) was obtained by electrochemical oxidation of ruthenium nanoparticles immobilised on the glassy carbon electrode (GCE) surface and used for simultaneous electroanalysis of drugs. There are many discussions in the scientific community about the decrease in therapeutic efficacy of contraceptives when associated with antibiotics. The antibiotic effect of the antagonist can increase the contraceptive excretion levels in urine, indicating a reduction in the body and thus a decrease in the desired effect. Using the DPV technique, it was possible to quantify ethinylestradiol (EE2) and amoxicillin (AMX) with a linear response range, 5.50x10(-8) - 1.20x10(-6)mol L-1, and LOD, 2.04 nmol L-1 and 1.63 nmol L-1, respectively. The results for the electrochemical behaviour of EE2 and AMX using GCE/rGO/RuNP were compared with GCE/rGO and GCE. The GCE/rGO/RuNP showed greater stability and separation anodic peak currents, suitable for the quantification of organic molecules in samples of environmental interest, as well as clinical and food samples. (AU)

• Processo FAPESP: 16/12926-3 - Remoção e determinação em tempo real de poluentes ambientais utilizando sistema eletroquímico fotoassistido
• Beneficiário: Fernando Cruz de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16565-5 - Desenvolvimento de métodos ultrassensíveis para a detecção de RNA visando o diagnóstico de Câncer de Cabeça e Pescoço
• Beneficiário: Fernando Henrique Cincotto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado