Electrochemical Sensor-Based Ruthenium Nanoparticles on Reduced Graphene Oxide for the Simultaneous Determination of Ethinylestradiol and Amoxicillin

Author(s)

Prado, Thiago M. ; Cincotto, Fernando H. ; Moraes, Fernando C. ; Machado, Sergio A. S.

• Document type: Journal article
• Source: Electroanalysis; v. 29, n. 5, p. 1278-1285, MAY 2017.
• Web of Science Citations: 8

Abstract

The composite material of reduced graphene and Ru nanoparticles (rGO/RuNP) was obtained by electrochemical oxidation of ruthenium nanoparticles immobilised on the glassy carbon electrode (GCE) surface and used for simultaneous electroanalysis of drugs. There are many discussions in the scientific community about the decrease in therapeutic efficacy of contraceptives when associated with antibiotics. The antibiotic effect of the antagonist can increase the contraceptive excretion levels in urine, indicating a reduction in the body and thus a decrease in the desired effect. Using the DPV technique, it was possible to quantify ethinylestradiol (EE2) and amoxicillin (AMX) with a linear response range, 5.50x10(-8) - 1.20x10(-6)mol L-1, and LOD, 2.04 nmol L-1 and 1.63 nmol L-1, respectively. The results for the electrochemical behaviour of EE2 and AMX using GCE/rGO/RuNP were compared with GCE/rGO and GCE. The GCE/rGO/RuNP showed greater stability and separation anodic peak currents, suitable for the quantification of organic molecules in samples of environmental interest, as well as clinical and food samples. (AU)

• FAPESP's process: 16/12926-3 - Removal and real time determination of environmental pollutants using electrochemical photoassisted system
• Grantee: Fernando Cruz de Moraes
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/16565-5 - Development of ultra-sensitive methods for RNA detection for the diagnosis of Head and Neck Cancer
• Grantee: Fernando Henrique Cincotto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral