Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

Autor(es)

de Oliveira, Marlia Garcia ; Oliveira, Luana de Mendonca ; de Lima Lira, Aline Aparecida ; Sgnotto, Fabio da Ressureicao ; da Silva Duarte, Alberto Jose ; Sato, Maria Notomi ; Victor, Jefferson Russo

• Tipo de documento: Artigo Científico
• Fonte: ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY; v. 13, APR 17 2017.
• Citações Web of Science: 7

Resumo

Background: The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition. Methods: C57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their offspring were evaluated at 3 days of age or 20 days after neonatal immunization. Human peripheral B cells from atopic and non-atopic individuals were also evaluated. Results: Preconception OVA immunization induced B10 cells in offspring, and IL-10 production appeared to be critical for FcyRIIB upregulation in offspring B cells. Murine and human IL-10-producing B cells responded in vitro to IgG according to the atopic repertoire of the cells. Conclusions: Our results reveal that maternal immunization induces allergen-specific B10 cells in offspring and a pivotal role for the IgG repertoire in IL-10 production by murine and human B cells. (AU)

• Processo FAPESP: 13/22820-0 - "Influência da imunização materna com Ovalbumina na maturação tímica de linfócitos TCD4+, TCD8+, nTreg, Tgd e B da prole"
• Beneficiário: Marília Garcia de Oliveira
• Linha de fomento: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/09004-0 - IMUNIZAÇÃO MATERNA COM OVALBUMINA NA PREVENÇÃO DA RESPOSTA ALÉRGICA NA PROLE: PAPEL DOS RECEPTORES INIBIDORES FCgammaRIIB E ASPECTOS FUNCIONAIS MEDIADOS POR CÉLULAS E CITOCINAS REGULADORAS
• Beneficiário: Jefferson Russo Victor
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/17256-3 - "Investigação dos mecanismos de inibição da resposta de hipersensibilidade tipo I da prole mediada pela imunização materna murina: modulação de citocinas, indução de linfócitos T e B reguladores e influência da natureza do alérgeno."
• Beneficiário: Alberto José da Silva Duarte
• Linha de fomento: Auxílio à Pesquisa - Regular