Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

Autor(es):Mostrar menos -

Carrenho Queiroz, Andreia Cristiane ; Silva Jr Sousa, Julio Cesar ; Silva, Jr., Natan Daniel ; Tobaldini, Eleonora ; Ortega, Katia Coelho ; De Oliveira, Edilamar Menezes ; Brum, Patricia Chakur ; Montano, Nicola ; Mion, Jr., Decio ; Tinucci, Tais ; De Moraes Forjaz, Claudia Lucia

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 38, n. 4, p. 270-277, APR 2017.
• Citações Web of Science: 4

Resumo

To evaluate whether captopril (3 x 50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C - rest) and Resistance Exercise (RE - 7 exercises, 3 sets to moderate fatigue, 50 % of 1 RM-repetition maximum). Measurements were taken before and after 30-60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo = -13 +/- 2/ -9 +/- 1 mmHg vs. Captopril = -12 +/- 2/ -10 +/- 1 mmHg, P < 0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: + 13 +/- 2 bpm, + 21 +/- 5 nu, -11 +/- 5 ml, -4 +/- 2 ms/mmHg; Captopril: + 13 +/- 2 bpm, + 35 +/- 4 nu, 17 +/- 5 ml, -3 +/- 1 ms/mmHg, P < 0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms. (AU)

• Processo FAPESP: 11/06689-5 - Hipotensão pós-exercício resistido em homens hipertensos: influência do uso de captopril
• Beneficiário: Cláudia Lúcia de Moraes Forjaz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/18219-3 - Hipotensão pós-exercício resistido em homens hipertensos: influência do uso de captopril.
• Beneficiário: Andréia Cristiane Carrenho Queiroz
• Modalidade de apoio: Bolsas no Brasil - Doutorado